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Conference Paper: Increased expression of Vascular Endothelial Growth Factor-C in papillary thyroid carcinoma predicts cervical lymph node metastasis

TitleIncreased expression of Vascular Endothelial Growth Factor-C in papillary thyroid carcinoma predicts cervical lymph node metastasis
Authors
Issue Date2005
PublisherAmerican Association for Cancer Research
Citation
AACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 1145 Abstract no. 4848 How to Cite?
AbstractVascular endothelial growth factor C (VEGF-C), a critical tumor lymphangiogenic factor involved in nodal metastases, is suspected to initiate cervical lymph node metastases in papillary thyroid carcinoma (PTC). The purpose of this study is to investigate the expression pattern of VEGF-C in PTC and examine its correlation with any clinicopathologic features. Paired tissues from PTC (n=39) and benign thyroid nodules (n=20) were analyzed for VEGF-C protein expression level and localization using semi-quantitative Western blot analysis and immunohistochemistry, respectively. VEGF-C expression was detected in 27 of 39 PTC, but only 1 out of 20 nodular hyperplasia specimens (p<0.001). Its expression was higher in tumor compared with adjacent non-tumorous tissues while adjacent non-tumorous tissue in metastatic PTC had a significantly higher VEGF-C expression compared with that of non-metastatic PTC tissues (p=0.011). Positive immunohistochemical staining for VEGF-C was observed in both tumors with and without lymph node metastases but not in sections from benign thyroid disease. VEGF-C expression level in PTC correlated significantly with lymph node metastasis and lymph vessel permeation (p=0.004 and 0.001 respectively). In conclusion, over-expression of VEGF-C protein in PTC may predict cervical lymph node metastases, and increased level of VEGF-C in adjacent non-tumorous tissue of the metastatic PTC was probably involved in the process of intrathyroidal lymphangiogenesis and micro-metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/107978
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorYu, XMen_HK
dc.contributor.authorLo, CYen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLeung, Pen_HK
dc.contributor.authorLuk, JMCen_HK
dc.date.accessioned2010-09-26T00:20:21Z-
dc.date.available2010-09-26T00:20:21Z-
dc.date.issued2005en_HK
dc.identifier.citationAACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 1145 Abstract no. 4848-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/107978-
dc.description.abstractVascular endothelial growth factor C (VEGF-C), a critical tumor lymphangiogenic factor involved in nodal metastases, is suspected to initiate cervical lymph node metastases in papillary thyroid carcinoma (PTC). The purpose of this study is to investigate the expression pattern of VEGF-C in PTC and examine its correlation with any clinicopathologic features. Paired tissues from PTC (n=39) and benign thyroid nodules (n=20) were analyzed for VEGF-C protein expression level and localization using semi-quantitative Western blot analysis and immunohistochemistry, respectively. VEGF-C expression was detected in 27 of 39 PTC, but only 1 out of 20 nodular hyperplasia specimens (p<0.001). Its expression was higher in tumor compared with adjacent non-tumorous tissues while adjacent non-tumorous tissue in metastatic PTC had a significantly higher VEGF-C expression compared with that of non-metastatic PTC tissues (p=0.011). Positive immunohistochemical staining for VEGF-C was observed in both tumors with and without lymph node metastases but not in sections from benign thyroid disease. VEGF-C expression level in PTC correlated significantly with lymph node metastasis and lymph vessel permeation (p=0.004 and 0.001 respectively). In conclusion, over-expression of VEGF-C protein in PTC may predict cervical lymph node metastases, and increased level of VEGF-C in adjacent non-tumorous tissue of the metastatic PTC was probably involved in the process of intrathyroidal lymphangiogenesis and micro-metastasis.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleIncreased expression of Vascular Endothelial Growth Factor-C in papillary thyroid carcinoma predicts cervical lymph node metastasisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLo, CY: cylo@hkucc.hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.identifier.hkuros108191en_HK

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