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Conference Paper: L1CAM-dependent NFκB activation upregulates fascin expression and augments tumor cell invasion and motility

TitleL1CAM-dependent NFκB activation upregulates fascin expression and augments tumor cell invasion and motility
Authors
Issue Date2007
PublisherAmerican Association for Cancer Research
Citation
AACR 98th Annual Meeting, Los Angeles, CA, 14–18 April 2007. In Cancer Research, 2007, v. 67 n. 9S, p. 1347 How to Cite?
AbstractCell migration and invasion are fundamental components of tumor cell metastasis, which contributed to the poor prognosis of hepatocellular carcinoma (HCC). Establishment of a pair of metastatic HCC cell lines (MHCC97L and MHCC97H) provide an indispensable tool to study the molecular mechanism of HCC metastasis. By comparing the genetic alterations between these two cell lines by cDNA microarray analysis, we identified the neuronalcell adhesion molecule L1- mediated signalling as a key event HCC metastasis. L1CAM was significantly associated with HCC metastasis in HCC tissue microarray (p<0.001). Ectopic L1CAM increased HCC cell motility and invasion by modulation of F-actin structure, and induced HCC metastasis in a metastatic HCC nude mice model. Fascin, a key actin binding protein, was first identified as a downstream target of L1CAM mediated HCC cell motility and invasiveness.L1CAM over-expression was significantly correlated with fascin expression in tissue microarray (p=0.007). L1CAM was found to activate fascin promoter through NFκB activation. The RGD sites in the Ig domain 6 of L1CAM was responsible for NFκB dependent fascin over-expression by interaction with αvβ5, augmenting HCC cell invasion and motility. In conclusion, our results demonstrated the significance of L1CAM in HCC. Fascin is an important for L1CAM mediated downstream effects, augmenting cell motility and invasiveness.
Persistent Identifierhttp://hdl.handle.net/10722/107932
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorLee, KWen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorAltevogt, Pen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-26T00:18:26Z-
dc.date.available2010-09-26T00:18:26Z-
dc.date.issued2007en_HK
dc.identifier.citationAACR 98th Annual Meeting, Los Angeles, CA, 14–18 April 2007. In Cancer Research, 2007, v. 67 n. 9S, p. 1347-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/107932-
dc.description.abstractCell migration and invasion are fundamental components of tumor cell metastasis, which contributed to the poor prognosis of hepatocellular carcinoma (HCC). Establishment of a pair of metastatic HCC cell lines (MHCC97L and MHCC97H) provide an indispensable tool to study the molecular mechanism of HCC metastasis. By comparing the genetic alterations between these two cell lines by cDNA microarray analysis, we identified the neuronalcell adhesion molecule L1- mediated signalling as a key event HCC metastasis. L1CAM was significantly associated with HCC metastasis in HCC tissue microarray (p<0.001). Ectopic L1CAM increased HCC cell motility and invasion by modulation of F-actin structure, and induced HCC metastasis in a metastatic HCC nude mice model. Fascin, a key actin binding protein, was first identified as a downstream target of L1CAM mediated HCC cell motility and invasiveness.L1CAM over-expression was significantly correlated with fascin expression in tissue microarray (p=0.007). L1CAM was found to activate fascin promoter through NFκB activation. The RGD sites in the Ig domain 6 of L1CAM was responsible for NFκB dependent fascin over-expression by interaction with αvβ5, augmenting HCC cell invasion and motility. In conclusion, our results demonstrated the significance of L1CAM in HCC. Fascin is an important for L1CAM mediated downstream effects, augmenting cell motility and invasiveness.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleL1CAM-dependent NFκB activation upregulates fascin expression and augments tumor cell invasion and motilityen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLee, KW: tkwlee@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailYuen, PW: pwyuen@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLee, KW=rp00447en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.hkuros140993en_HK

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