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Conference Paper: Hedgehog signaling in human hepatocellular carcinoma

TitleHedgehog signaling in human hepatocellular carcinoma
Authors
Issue Date2005
PublisherAmerican Association for Cancer Research
Citation
AACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 928 Abstract no. 3942 How to Cite?
AbstractHepatocellular carcinoma (HCC) is the fourth most common malignancy and one of the leading causes of death world wide. Signaling pathways important for tumor initiation and progression in HCC are poorly understood. Hedgehog signaling (Hh) has been implicated in multiple events during development and has also been proposed to play important roles in several tumor types. However, it remains unclear whether this pathway is activated in HCC. We report signaling molecules in the hedgehog pathway that are expressed in both HCC cell lines and tumor samples. Quantitative real-time RT-PCR also reviewed the decreased expression of Hip1 and increased expression of Gli1 and smo in HCC samples compared with non-tumor liver tissues. Blocking the hedgehog pathway with cyclopamine inhibits proliferation, induces apoptosis and repressed Myc-c and cyclin D expression in a subset of HCC cell lines. The study therefore for the first time provides evidence that hedgehog signaling is activated in HCC. The results also indicate that the hedgehog pathway may be a new candidate for therapeutic targeting in HCC.
Persistent Identifierhttp://hdl.handle.net/10722/107758
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorPatil, MAen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorHo, Cen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorChen, Xen_HK
dc.date.accessioned2010-09-26T00:11:11Z-
dc.date.available2010-09-26T00:11:11Z-
dc.date.issued2005en_HK
dc.identifier.citationAACR 96th Annual Meeting, Anaheim CA, 16–20 April 2005. In Cancer Research, 2005, v. 65 n. 9S, p. 928 Abstract no. 3942-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/107758-
dc.description.abstractHepatocellular carcinoma (HCC) is the fourth most common malignancy and one of the leading causes of death world wide. Signaling pathways important for tumor initiation and progression in HCC are poorly understood. Hedgehog signaling (Hh) has been implicated in multiple events during development and has also been proposed to play important roles in several tumor types. However, it remains unclear whether this pathway is activated in HCC. We report signaling molecules in the hedgehog pathway that are expressed in both HCC cell lines and tumor samples. Quantitative real-time RT-PCR also reviewed the decreased expression of Hip1 and increased expression of Gli1 and smo in HCC samples compared with non-tumor liver tissues. Blocking the hedgehog pathway with cyclopamine inhibits proliferation, induces apoptosis and repressed Myc-c and cyclin D expression in a subset of HCC cell lines. The study therefore for the first time provides evidence that hedgehog signaling is activated in HCC. The results also indicate that the hedgehog pathway may be a new candidate for therapeutic targeting in HCC.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleHedgehog signaling in human hepatocellular carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.hkuros108587en_HK

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