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Conference Paper: Correlation of ADC on DWI and SUV max on PET/CT in primary rectal cancer: a preliminary experience

TitleCorrelation of ADC on DWI and SUV max on PET/CT in primary rectal cancer: a preliminary experience
Authors
Issue Date2009
PublisherRSNA 2009.
Citation
The 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2009), Chicago, IL., 29 November-4 December 2009. How to Cite?
AbstractPURPOSE: Diffusion weighted imaging (DWI) is an emerging, whereas PET/CT an established tool for tumor assessment. Tumors often demonstrate decreased apparent diffusion coefficient (ADC) on DWI, and increased standard uptake value (SUV) on FDG-PET/CT. The aim of this study was to assess the relationship between ADC and SUV in primary rectal cancer. METHOD AND MATERIALS: From Nov 08 to Apr 09, 16 consecutive patients (10 men, 6 women; age 55-88 years) with pathologically proven rectal cancer and having undergone both MRI and PET/CT were included in this study. All MRs were performed on a 3T scanner (Achieva, Philips). Routine T1, T2, DWI and contrast-enhanced sequences were obtained. Axial pelvic DWI was obtained by single-shot EPI with STIR fat-suppression and slice-selection gradient reversal technique (TR/TE/TI=7779/47/260ms, matrix 188×151, FOV 40×32 cm, b-value=0 and 1000 s/mm2, slice thickness 5mm). ROIs were manually drawn along contours of the tumor on each slice of ADC maps covering the entire tumor. ADC values were calculated by Image J software (NIH, US). ADCmean was defined as average ADC value for all voxels in each tumor, and ADCmin as the lowest ADC value among all voxels in each tumor. All PET/CT exams (Discovery VCT, GE) were performed within 1 week of MRI. A 3D ROI was placed over the entire tumor on Advanced Workstation (GE) to calculate SUVmax. Maximum diameter of the tumor was measured on both MRI (M_D) and PET/CT (P_D). Relationship between ADC and SUVmax values was assessed by pearsons correlation test. RESULTS: ADCmean and ADCmin for all tumors were 0.96±0.23 and 0.37±0.19 (10-3mm2/s) respectively. SUVmax values were 10.55±6.13. M_D values were 5.78±2.19 cm and P_D 6.11±2.12 cm. Statistically significant negative correlation was found between ADCmin and SUVmax (r=-0.57, p=0.02), and ADCmean and SUVmax (r=-0.65, p=0.006). M_D was significantly correlated with P_D (r=0.49, p=0.02). CONCLUSION: Our preliminary results showed that both ADCmin and ADCmean of the primary rectal cancer are inversely correlated with SUVmax, which has been shown to correlate with tumor aggressiveness and treatment response in many malignancies. CLINICAL RELEVANCE/APPLICATION: ADC values may be potential surrogate biomarkers for detection, characterization, prognostication and monitoring treatment response of rectal cancer.
DescriptionSession - SST04: Gastrointestinal (Rectal Cancer: Advanced Imaging)
Persistent Identifierhttp://hdl.handle.net/10722/107496

 

DC FieldValueLanguage
dc.contributor.authorGu, Jen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorLiu, RKY-
dc.contributor.authorZhang, J-
dc.contributor.authorQiu, D-
dc.contributor.authorZhang, Z-
dc.contributor.authorChan, Q-
dc.date.accessioned2010-09-26T00:00:05Z-
dc.date.available2010-09-26T00:00:05Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2009), Chicago, IL., 29 November-4 December 2009.-
dc.identifier.urihttp://hdl.handle.net/10722/107496-
dc.descriptionSession - SST04: Gastrointestinal (Rectal Cancer: Advanced Imaging)-
dc.description.abstractPURPOSE: Diffusion weighted imaging (DWI) is an emerging, whereas PET/CT an established tool for tumor assessment. Tumors often demonstrate decreased apparent diffusion coefficient (ADC) on DWI, and increased standard uptake value (SUV) on FDG-PET/CT. The aim of this study was to assess the relationship between ADC and SUV in primary rectal cancer. METHOD AND MATERIALS: From Nov 08 to Apr 09, 16 consecutive patients (10 men, 6 women; age 55-88 years) with pathologically proven rectal cancer and having undergone both MRI and PET/CT were included in this study. All MRs were performed on a 3T scanner (Achieva, Philips). Routine T1, T2, DWI and contrast-enhanced sequences were obtained. Axial pelvic DWI was obtained by single-shot EPI with STIR fat-suppression and slice-selection gradient reversal technique (TR/TE/TI=7779/47/260ms, matrix 188×151, FOV 40×32 cm, b-value=0 and 1000 s/mm2, slice thickness 5mm). ROIs were manually drawn along contours of the tumor on each slice of ADC maps covering the entire tumor. ADC values were calculated by Image J software (NIH, US). ADCmean was defined as average ADC value for all voxels in each tumor, and ADCmin as the lowest ADC value among all voxels in each tumor. All PET/CT exams (Discovery VCT, GE) were performed within 1 week of MRI. A 3D ROI was placed over the entire tumor on Advanced Workstation (GE) to calculate SUVmax. Maximum diameter of the tumor was measured on both MRI (M_D) and PET/CT (P_D). Relationship between ADC and SUVmax values was assessed by pearsons correlation test. RESULTS: ADCmean and ADCmin for all tumors were 0.96±0.23 and 0.37±0.19 (10-3mm2/s) respectively. SUVmax values were 10.55±6.13. M_D values were 5.78±2.19 cm and P_D 6.11±2.12 cm. Statistically significant negative correlation was found between ADCmin and SUVmax (r=-0.57, p=0.02), and ADCmean and SUVmax (r=-0.65, p=0.006). M_D was significantly correlated with P_D (r=0.49, p=0.02). CONCLUSION: Our preliminary results showed that both ADCmin and ADCmean of the primary rectal cancer are inversely correlated with SUVmax, which has been shown to correlate with tumor aggressiveness and treatment response in many malignancies. CLINICAL RELEVANCE/APPLICATION: ADC values may be potential surrogate biomarkers for detection, characterization, prognostication and monitoring treatment response of rectal cancer.-
dc.languageengen_HK
dc.publisherRSNA 2009.-
dc.relation.ispartof95th RSNA Scientific Assembly and Annual Meeting 2009en_HK
dc.titleCorrelation of ADC on DWI and SUV max on PET/CT in primary rectal cancer: a preliminary experienceen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKhong, PL: plkhong@hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.emailLiu, RKY: ricoliu@hkucc.hku.hk-
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros169251en_HK
dc.publisher.placeUnited States-

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