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Conference Paper: Maximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation)

TitleMaximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation)
Authors
Issue Date2004
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASH
Citation
The 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004. In Annals of the College of Surgeons of Hong Kong, 2004, v. 8 n. 2 Suppl, p. A7, abstract no. 25 How to Cite?
AbstractThis is an in vivo study on normal and cirrhotic Sprague-Dawlay rats to investigate the possible systemic responses of large-volume hepatic radiofrequency ablation and to estimate its maximal host tolerance. Cool-tip® RF System was used to ablate different percentage of liver volume in normal and cirrhotic rats. Systemic responses in terms of systemic inflammatory marker changes and end-organ functions were determined. For the normal liver groups, the concentrations of systemic inflammatory markers were significantly elevated in early postoperative period when 50 and 60% of the liver volume were ablated, compared with the control group. Derangement of coagulation profile and interstitial penumonitis occurred after 50 and 60% of the liver volume were ablated. The survival rate was 100%, 60% and 0% when 40%, 50% and 60% of liver volume were ablated, respectively. Similar systemic responses were observed among the cirrhotic liver groups when 30 and 40% of the liver volume were ablated. The survival rate was 100%, 40% and 0% when 20%, 30% and 40% of the cirrhotic liver were ablated, respectively. The normal rats can tolerate hepatic RFA procedure maximally when 40% of the liver volume is ablated, whereas the cirrhotic rats can only tolerate RFA of 20% of the liver volume.
Persistent Identifierhttp://hdl.handle.net/10722/107490
ISSN

 

DC FieldValueLanguage
dc.contributor.authorNg, KKCen_HK
dc.contributor.authorLam, CMen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-25T23:59:49Z-
dc.date.available2010-09-25T23:59:49Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004. In Annals of the College of Surgeons of Hong Kong, 2004, v. 8 n. 2 Suppl, p. A7, abstract no. 25-
dc.identifier.issn1028-4001-
dc.identifier.urihttp://hdl.handle.net/10722/107490-
dc.description.abstractThis is an in vivo study on normal and cirrhotic Sprague-Dawlay rats to investigate the possible systemic responses of large-volume hepatic radiofrequency ablation and to estimate its maximal host tolerance. Cool-tip® RF System was used to ablate different percentage of liver volume in normal and cirrhotic rats. Systemic responses in terms of systemic inflammatory marker changes and end-organ functions were determined. For the normal liver groups, the concentrations of systemic inflammatory markers were significantly elevated in early postoperative period when 50 and 60% of the liver volume were ablated, compared with the control group. Derangement of coagulation profile and interstitial penumonitis occurred after 50 and 60% of the liver volume were ablated. The survival rate was 100%, 60% and 0% when 40%, 50% and 60% of liver volume were ablated, respectively. Similar systemic responses were observed among the cirrhotic liver groups when 30 and 40% of the liver volume were ablated. The survival rate was 100%, 40% and 0% when 20%, 30% and 40% of the cirrhotic liver were ablated, respectively. The normal rats can tolerate hepatic RFA procedure maximally when 40% of the liver volume is ablated, whereas the cirrhotic rats can only tolerate RFA of 20% of the liver volume.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ASH-
dc.relation.ispartofThe 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004en_HK
dc.titleMaximal host tolerance to large-volume hepatic radiofrequency ablation in a rat model (Oral Presentation)en_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLam, CM: drcmlam@hkma.orgen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailShek, TWH: whshek@HKUCC.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.doi10.1111/j.1442-2034.2004.207_25.x-
dc.identifier.hkuros92390en_HK
dc.identifier.hkuros92399-
dc.description.otherThe 11th Annual Scientific Meeting of the College of Surgeons of Hong Kong, Hong Kong, 5-6 June 2004. In Annals of the College of Surgeons of Hong Kong, 2004, v. 8 n. 2 Suppl, p. A7, abstract no. 25-

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