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Conference Paper: Impact of donor age on right lobe living donor liver transplantation in a single centre

TitleImpact of donor age on right lobe living donor liver transplantation in a single centre
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The International Liver Transplantation Society: 15th Annual International Congress, New York City, N.Y., 8 - 11 July 2009. How to Cite?
AbstractBackground: With limited availability of deceased donor, living donor from a family member accounted for the majority of liver transplantation as a definitive or even life-saving treatment for end-stage liver disease in Hong Kong. The impact of donor age on the outcomes of both donor hepatectomy and living donor liver transplantation had not been clarified. Methods: We performed retrospective analysis of recipients of right lobe living donor liver transplantation (RL LDLT) between May 1996 and December 2007 in our centre by same team of surgeons. Patients were divided into 2 groups, donor age ≤45 years (group A) and >45 years (group B). Blood loss, operation time, and post-operative complications of donor right hepatectomy were compared. Graft survival, acute cellular rejection, and post-operative complications of recipients were also compared. Results: There were 287 RL LDLT performed in this period, 230(80%) patients in group A and 57(20%) in group B. There was signifi cantly more female donors in group B (60% vs. 80%, p=0.004). Operation time in both groups were comparable (454 minutes vs. 458minutes, p=0.448). Donor right hepatectomy in group B had more blood loss (312ml vs. 389ml, p=0.035), and longer hospital stay (7 days vs. 9 days, p=0.003). The complication rates between two groups of donors were comparable (17% vs. 15.8%, p=0.833). There was no significant difference in liver function between two groups within first week after operation. There was no hospital mortality of donors in both groups.For recipients, both groups had comparable demographic characteristics, MELD scores and percentage of graft weight to estimated standard liver volume (ESLV). Post-operative complication rate were 55.2% vs. 57.9% (p=0.716). Incidence of acute cellular rejection were 16.5% vs. 19.3% (p=0.618). 1-, 3- and 5-year graft survivals among two groups were comparable (93%, 86%, 82% vs. 93%, 84%, 79%, p=0.47). Conclusion: Provided stringent selection protocol and standardized surgical technique, right hepatectomy was safe for older donor. Impact of donor age was not significant on outcomes of living donor liver transplantation.
DescriptionLiver Transplantation, 2009, v. 15 n. Suppl 7, p. S92 Abstract no. O-69
Persistent Identifierhttp://hdl.handle.net/10722/107192
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorSharr, WWen_HK
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorNg, KKCen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-25T23:47:26Z-
dc.date.available2010-09-25T23:47:26Z-
dc.date.issued2009en_HK
dc.identifier.citationThe International Liver Transplantation Society: 15th Annual International Congress, New York City, N.Y., 8 - 11 July 2009.en_HK
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/107192-
dc.descriptionLiver Transplantation, 2009, v. 15 n. Suppl 7, p. S92 Abstract no. O-69-
dc.description.abstractBackground: With limited availability of deceased donor, living donor from a family member accounted for the majority of liver transplantation as a definitive or even life-saving treatment for end-stage liver disease in Hong Kong. The impact of donor age on the outcomes of both donor hepatectomy and living donor liver transplantation had not been clarified. Methods: We performed retrospective analysis of recipients of right lobe living donor liver transplantation (RL LDLT) between May 1996 and December 2007 in our centre by same team of surgeons. Patients were divided into 2 groups, donor age ≤45 years (group A) and >45 years (group B). Blood loss, operation time, and post-operative complications of donor right hepatectomy were compared. Graft survival, acute cellular rejection, and post-operative complications of recipients were also compared. Results: There were 287 RL LDLT performed in this period, 230(80%) patients in group A and 57(20%) in group B. There was signifi cantly more female donors in group B (60% vs. 80%, p=0.004). Operation time in both groups were comparable (454 minutes vs. 458minutes, p=0.448). Donor right hepatectomy in group B had more blood loss (312ml vs. 389ml, p=0.035), and longer hospital stay (7 days vs. 9 days, p=0.003). The complication rates between two groups of donors were comparable (17% vs. 15.8%, p=0.833). There was no significant difference in liver function between two groups within first week after operation. There was no hospital mortality of donors in both groups.For recipients, both groups had comparable demographic characteristics, MELD scores and percentage of graft weight to estimated standard liver volume (ESLV). Post-operative complication rate were 55.2% vs. 57.9% (p=0.716). Incidence of acute cellular rejection were 16.5% vs. 19.3% (p=0.618). 1-, 3- and 5-year graft survivals among two groups were comparable (93%, 86%, 82% vs. 93%, 84%, 79%, p=0.47). Conclusion: Provided stringent selection protocol and standardized surgical technique, right hepatectomy was safe for older donor. Impact of donor age was not significant on outcomes of living donor liver transplantation.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantationen_HK
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleImpact of donor age on right lobe living donor liver transplantation in a single centreen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1527-6465&volume=15&issue=Suppl 7&spage=S92 Abstract no. O&epage=69&date=2009&atitle=Impact+of+donor+age+on+right+lobe+living+donor+liver+transplantation+in+a+single+centre-
dc.identifier.emailNg, KKC: kkcng@HKUCC.hku.hken_HK
dc.identifier.emailChan, SC: chanlsc@HKUCC.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.doi10.1002/lt.21830-
dc.identifier.hkuros162019en_HK
dc.identifier.hkuros170112-
dc.identifier.volume15en_HK
dc.identifier.issueSuppl 7en_HK
dc.identifier.spageS92 Abstract no. O-69en_HK
dc.identifier.epageS92 Abstract no. O-69-

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