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Conference Paper: Short-term cardiotrophin-1 (CT-1) rescues marginalcirrhotic liver remnant after major hepatectomywithout increasing the risk of tumor recurrence

TitleShort-term cardiotrophin-1 (CT-1) rescues marginalcirrhotic liver remnant after major hepatectomywithout increasing the risk of tumor recurrence
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Asia
Citation
Shanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A92 How to Cite?
AbstractBackground Hepatic resection is not applicable to the majority ofhepatocellular carcinoma (HCC) patients due to insufficient liverfunction reserve. Cardiotrophin-1 (CT-1), a member of the inter-leukin-6 family, has demonstrated protective and pro-proliferativeeffects in the myocytes and hepatocytes.Aim The present study aimed to investigate the potential role ofCT-1 in rescuing marginal cirrhotic liver remnant in a rat orthotopicHCC model.Materials and Methods Liver cirrhosis was induced by subcuta-neous injection of CCL4 for 8 weeks. The rat orthotopic HCC model was generated by injecting HCC cells into the left lobe of the liver.Animals received the following treatments: 1) hepatectomy only, n =6; 2) CT-1 (2 µg/kg) intraportal vein injection (i.pv) right after hepa-tectomy, n = 6; 3) CT-1 (2 µg/kg) i.pv right after hepatectomy, and 1µg/kg intraperitoneal injection (i.p) 24 hr after hepatectomy, n = 6; 4)CT-1 (2 µg/kg) i.p 24 hr before hepatectomy, n = 6; 5) CT-1 (2 µg/kg)i.p 24 hr before hepatectomy, and 1 µg/kg i.p 24 hr after hepatectomy,n = 6.Results The double-dose CT-1 significantly improved animal survival, and all the surviving animals did not present with tumorrecurrence. CT-1 administration decreased the plasma AST and ALT levels, augmented the number of Ki-67+and gp130+cells, andrestored the ATP levels. CT-1 culture enhanced the viability of pri-marily isolated hepatocytes. CT-1 treatment increased the expressionof Akt and PI3K in the liver remnant.Conclusions A short-term administration of CT-1 could improveanimal survival after major hepatectomy, through promoting cell pro-liferation and restoring cell survival.
Persistent Identifierhttp://hdl.handle.net/10722/107160
ISSN
2014 Impact Factor: 3.504
2014 SCImago Journal Rankings: 1.128

 

DC FieldValueLanguage
dc.contributor.authorYang, Zen_HK
dc.contributor.authorLau, CKen_HK
dc.contributor.authorNgai, PPen_HK
dc.contributor.authorHo, DWYen_HK
dc.contributor.authorTam, KHen_HK
dc.contributor.authorLam, CTen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-09-25T23:46:05Z-
dc.date.available2010-09-25T23:46:05Z-
dc.date.issued2006en_HK
dc.identifier.citationShanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A92en_HK
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/107160-
dc.description.abstractBackground Hepatic resection is not applicable to the majority ofhepatocellular carcinoma (HCC) patients due to insufficient liverfunction reserve. Cardiotrophin-1 (CT-1), a member of the inter-leukin-6 family, has demonstrated protective and pro-proliferativeeffects in the myocytes and hepatocytes.Aim The present study aimed to investigate the potential role ofCT-1 in rescuing marginal cirrhotic liver remnant in a rat orthotopicHCC model.Materials and Methods Liver cirrhosis was induced by subcuta-neous injection of CCL4 for 8 weeks. The rat orthotopic HCC model was generated by injecting HCC cells into the left lobe of the liver.Animals received the following treatments: 1) hepatectomy only, n =6; 2) CT-1 (2 µg/kg) intraportal vein injection (i.pv) right after hepa-tectomy, n = 6; 3) CT-1 (2 µg/kg) i.pv right after hepatectomy, and 1µg/kg intraperitoneal injection (i.p) 24 hr after hepatectomy, n = 6; 4)CT-1 (2 µg/kg) i.p 24 hr before hepatectomy, n = 6; 5) CT-1 (2 µg/kg)i.p 24 hr before hepatectomy, and 1 µg/kg i.p 24 hr after hepatectomy,n = 6.Results The double-dose CT-1 significantly improved animal survival, and all the surviving animals did not present with tumorrecurrence. CT-1 administration decreased the plasma AST and ALT levels, augmented the number of Ki-67+and gp130+cells, andrestored the ATP levels. CT-1 culture enhanced the viability of pri-marily isolated hepatocytes. CT-1 treatment increased the expressionof Akt and PI3K in the liver remnant.Conclusions A short-term administration of CT-1 could improveanimal survival after major hepatectomy, through promoting cell pro-liferation and restoring cell survival.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleShort-term cardiotrophin-1 (CT-1) rescues marginalcirrhotic liver remnant after major hepatectomywithout increasing the risk of tumor recurrenceen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYang, Z: zfyang@hkucc.hku.hken_HK
dc.identifier.emailLau, CK: lauck@HKUCC-COM.hku.hken_HK
dc.identifier.emailNgai, PP: ppngai@hotmail.comen_HK
dc.identifier.emailHo, DWY: davidho@HKUCC.hku.hken_HK
dc.identifier.emailTam, KH: chrishku@graduate.hku.hken_HK
dc.identifier.emailLam, CT: sctlam@graduate.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2006.04405.x-
dc.identifier.hkuros117098en_HK
dc.identifier.volume21en_HK
dc.identifier.issueS2en_HK
dc.identifier.spage92en_HK

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