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Conference Paper: Nineteen donor deaths following living donor liver transplantation: review of the worldwide experience

TitleNineteen donor deaths following living donor liver transplantation: review of the worldwide experience
Authors
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
World Transplant Congress (WTC), Boston, MA, 22-27 July 2006, In Transplantation, 2006, v. 82 n. 1 Suppl 3, p. 116 Abstract no. 146 How to Cite?
AbstractBackground: The risk of death after donor hepatectomy for living donor liver transplantation (LDLT) is unknown, because of the lack of a sufficient database to accurately determine the rate of this infrequent, but devastating outcome. In the absence of an accurate estimate of donor death, the medical literature contains anecdotal reports of donor deaths which in some cases are based on verbal reports, circularly references or unsubstantiated data. Because donor death is one of the most important outcomes of LDLT, we performed a comprehensive survey of the medical and lay literature to provide a better estimate of the total number of worldwide donor deaths. Methods: We reviewed all published articles from PubMed which reported donor outcomes from 1989 to February 2006 and the lay literature (using Google.com and www.refdesk.com/paper.html). We classified each death as “definitely,” “possible” or “unlikely” related to donor surgery. Results: There were 19 documented donor deaths and 1 donor in a chronic vegetative state (2 years after surgery), as shown in the Table. Thirteen and one additional vegetative donor were “definitely”, 2 were “possibly” and 4 were “unlikely” related to donor surgery. The estimated total number of LDLT’s performed worldwide is 7087. The estimated rate of donor death “definitely” related to donor surgery is 13/7087 or 0.18 % and the rate of donor death which is “definitely” (13 patients) or “possibly” (2 patients) related to the donor surgery is 15/7087or 0.21%. The most common cause of “definite” deaths was sepsis (5), liver failure (2), unknown (2), MI, CVA, pulmonary embolus and peptic ulcer (1 each) which occured at a (median/mean) 11/38 days after surgery. Conclusions: This analysis provides: 1) a source document of all identifiable living liver donor deaths, 2) a better estimate of donor death rate and 3) an impetus for centers with unreported deaths to submit these outcomes to the liver transplantation community.
Persistent Identifierhttp://hdl.handle.net/10722/106908
ISSN
2015 Impact Factor: 3.69
2015 SCImago Journal Rankings: 1.699

 

DC FieldValueLanguage
dc.contributor.authorKenison, JRen_HK
dc.contributor.authorAdam, Ren_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorTrotter, JFen_HK
dc.date.accessioned2010-09-25T23:35:34Z-
dc.date.available2010-09-25T23:35:34Z-
dc.date.issued2006en_HK
dc.identifier.citationWorld Transplant Congress (WTC), Boston, MA, 22-27 July 2006, In Transplantation, 2006, v. 82 n. 1 Suppl 3, p. 116 Abstract no. 146en_HK
dc.identifier.issn0041-1337en_HK
dc.identifier.urihttp://hdl.handle.net/10722/106908-
dc.description.abstractBackground: The risk of death after donor hepatectomy for living donor liver transplantation (LDLT) is unknown, because of the lack of a sufficient database to accurately determine the rate of this infrequent, but devastating outcome. In the absence of an accurate estimate of donor death, the medical literature contains anecdotal reports of donor deaths which in some cases are based on verbal reports, circularly references or unsubstantiated data. Because donor death is one of the most important outcomes of LDLT, we performed a comprehensive survey of the medical and lay literature to provide a better estimate of the total number of worldwide donor deaths. Methods: We reviewed all published articles from PubMed which reported donor outcomes from 1989 to February 2006 and the lay literature (using Google.com and www.refdesk.com/paper.html). We classified each death as “definitely,” “possible” or “unlikely” related to donor surgery. Results: There were 19 documented donor deaths and 1 donor in a chronic vegetative state (2 years after surgery), as shown in the Table. Thirteen and one additional vegetative donor were “definitely”, 2 were “possibly” and 4 were “unlikely” related to donor surgery. The estimated total number of LDLT’s performed worldwide is 7087. The estimated rate of donor death “definitely” related to donor surgery is 13/7087 or 0.18 % and the rate of donor death which is “definitely” (13 patients) or “possibly” (2 patients) related to the donor surgery is 15/7087or 0.21%. The most common cause of “definite” deaths was sepsis (5), liver failure (2), unknown (2), MI, CVA, pulmonary embolus and peptic ulcer (1 each) which occured at a (median/mean) 11/38 days after surgery. Conclusions: This analysis provides: 1) a source document of all identifiable living liver donor deaths, 2) a better estimate of donor death rate and 3) an impetus for centers with unreported deaths to submit these outcomes to the liver transplantation community.-
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.comen_HK
dc.relation.ispartofTransplantationen_HK
dc.rightsTransplantation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleNineteen donor deaths following living donor liver transplantation: review of the worldwide experienceen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1337&volume=82&spage=116&epage=&date=2006&atitle=Nineteen+donor+deaths+following+living+donor+liver+transplantation:+review+of+the+worldwide+experience+(Abstract)en_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.hkuros135520en_HK
dc.identifier.volume82en_HK
dc.identifier.spage116en_HK

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