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Conference Paper: Active metabolite of vitamin D acutely reduces endothelium-dependent contractions in the isolated SHR aorta

TitleActive metabolite of vitamin D acutely reduces endothelium-dependent contractions in the isolated SHR aorta
Authors
Issue Date2008
PublisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl
Citation
Experimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. Meeting Abstract Supplement, p. 1128.6 How to Cite?
AbstractRecent studies proved that vitamin D has cardiovascular effects besides regulating calcium homeostasis. Objectives: To study the effect of calcitriol (1,25-dihydroxyvitamin D3) on endothelium-dependent responses of the aorta of spontaneously hypertensive rats (SHR). Methods: Rings of aortae were suspended in organ chambers for isometric force measurement. Agonist-induced endothelium-dependent and independent responses as well as prostacyclin release were measured in the absence or presence of calcitriol. Cytosolic calcium concentration was monitored by confocal microscopy after incubation with fluorescent dyes, Fluo-4 and Fura-red. Results: Acetylcholine-induced relaxation was not affected by administration of calcitriol while the acetylcholine- and ATP-induced endothelium-dependent contractions were reduced compared to those obtained in the absence of the drug. This effect was not present if the calcium ionophore A23187 was used as agonist. Acetylcholine- but not A23187 -induced release of prostacylin was reduced by acute administration of calcitriol. Exposure to calcitriol reduced the increase in cytosolic free calcium concentration caused by acetylcholine in the endothelial cells. Conclusions: This study shows that calcitriol can modulate vascular tone by reducing the release of endothelium-derived contracting factor(s). (Partly supported by the CeDAR Foundation)
Persistent Identifierhttp://hdl.handle.net/10722/106802
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorWong, MSKen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorVanhoutte, PMGRen_HK
dc.date.accessioned2010-09-25T23:31:02Z-
dc.date.available2010-09-25T23:31:02Z-
dc.date.issued2008en_HK
dc.identifier.citationExperimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. Meeting Abstract Supplement, p. 1128.6en_HK
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/106802-
dc.description.abstractRecent studies proved that vitamin D has cardiovascular effects besides regulating calcium homeostasis. Objectives: To study the effect of calcitriol (1,25-dihydroxyvitamin D3) on endothelium-dependent responses of the aorta of spontaneously hypertensive rats (SHR). Methods: Rings of aortae were suspended in organ chambers for isometric force measurement. Agonist-induced endothelium-dependent and independent responses as well as prostacyclin release were measured in the absence or presence of calcitriol. Cytosolic calcium concentration was monitored by confocal microscopy after incubation with fluorescent dyes, Fluo-4 and Fura-red. Results: Acetylcholine-induced relaxation was not affected by administration of calcitriol while the acetylcholine- and ATP-induced endothelium-dependent contractions were reduced compared to those obtained in the absence of the drug. This effect was not present if the calcium ionophore A23187 was used as agonist. Acetylcholine- but not A23187 -induced release of prostacylin was reduced by acute administration of calcitriol. Exposure to calcitriol reduced the increase in cytosolic free calcium concentration caused by acetylcholine in the endothelial cells. Conclusions: This study shows that calcitriol can modulate vascular tone by reducing the release of endothelium-derived contracting factor(s). (Partly supported by the CeDAR Foundation)-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl-
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleActive metabolite of vitamin D acutely reduces endothelium-dependent contractions in the isolated SHR aortaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.hkuros152592en_HK
dc.identifier.spage119en_HK

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