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Conference Paper: The antimicrobial peptide cathelicidin promotes gastric ulcer healing in rats

TitleThe antimicrobial peptide cathelicidin promotes gastric ulcer healing in rats
Authors
Issue Date2006
PublisherElsevier.
WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, Los Angeles, CA., 20-25 May 2006. In Gastroenterology, 2006, v. 130, 4 suppl. 2, p. A-543, abstract T1691 How to Cite?
AbstractCathelicidin, an antimicrobial peptide, has been shown to promote cutaneous wound repair and reaches high levels in the gastric mucosa during infection and inflammation. We therefore investigated whether this peptide contributes to gastric ulcer healing in rats. Ulcer induction increased cathelicidin expression in the gastric mucosa. Further increase in expression of this peptide by local injection of cathelicidin-encoding plasmid promoted ulcer healing by enhancing cell proliferation and angiogenesis. Cathelicidin directly stimulated proliferation of cultured rat gastric epithelial cells (RGM-1), which was abolished by inhibitors of matrix metalloproteinase (MMP), epidermal growth factor (EGFR), or MAPK/ERK kinase (MEK). Cathelicidin also increased EGFR and ERK1/2 phosphorylation via a MMP-dependent mechanism. Knockdown of transforming growth factor α (TGFα), which is a ligand of EGFR, by small interfering RNA completely nullified the mitogenic signals evoked by cathelicidin in RGM-1 cells. These findings suggest that cathelicidin exhibits pro-healing activity in stomachs through TGFα-dependent transactivation of EGFR and its related signaling pathway to induce proliferation of gastric epithelial cells.
DescriptionAbstracts of the AGA Institute (pp. A-1-A-747)
Persistent Identifierhttp://hdl.handle.net/10722/106765
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorYang, YHen_HK
dc.contributor.authorTai, EKKen_HK
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorLam, EKYen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-25T23:29:30Z-
dc.date.available2010-09-25T23:29:30Z-
dc.date.issued2006en_HK
dc.identifier.citationDigestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, Los Angeles, CA., 20-25 May 2006. In Gastroenterology, 2006, v. 130, 4 suppl. 2, p. A-543, abstract T1691en_HK
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/106765-
dc.descriptionAbstracts of the AGA Institute (pp. A-1-A-747)-
dc.description.abstractCathelicidin, an antimicrobial peptide, has been shown to promote cutaneous wound repair and reaches high levels in the gastric mucosa during infection and inflammation. We therefore investigated whether this peptide contributes to gastric ulcer healing in rats. Ulcer induction increased cathelicidin expression in the gastric mucosa. Further increase in expression of this peptide by local injection of cathelicidin-encoding plasmid promoted ulcer healing by enhancing cell proliferation and angiogenesis. Cathelicidin directly stimulated proliferation of cultured rat gastric epithelial cells (RGM-1), which was abolished by inhibitors of matrix metalloproteinase (MMP), epidermal growth factor (EGFR), or MAPK/ERK kinase (MEK). Cathelicidin also increased EGFR and ERK1/2 phosphorylation via a MMP-dependent mechanism. Knockdown of transforming growth factor α (TGFα), which is a ligand of EGFR, by small interfering RNA completely nullified the mitogenic signals evoked by cathelicidin in RGM-1 cells. These findings suggest that cathelicidin exhibits pro-healing activity in stomachs through TGFα-dependent transactivation of EGFR and its related signaling pathway to induce proliferation of gastric epithelial cells.-
dc.languageengen_HK
dc.publisherElsevier.-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro-
dc.relation.ispartofGastroenterologyen_HK
dc.titleThe antimicrobial peptide cathelicidin promotes gastric ulcer healing in ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, KK: wukakei@graduate.hku.hken_HK
dc.identifier.emailYang, Y: yangyhcn@hotmail.comen_HK
dc.identifier.emailTai, KK: emilytai@hellokitty.comen_HK
dc.identifier.emailWong, HPS: a9604488@graduate.hku.hken_HK
dc.identifier.emailLam, KY: emily_kylam_@hotmail.comen_HK
dc.identifier.emailShin, VY: vyshin@hku.hken_HK
dc.identifier.emailCho, CH: chcho@hkusua.hku.hken_HK
dc.identifier.doi10.1016/S0016-5085(06)60008-5-
dc.identifier.hkuros119515en_HK
dc.identifier.volume130en_HK
dc.identifier.issue4 suppl. 2-
dc.identifier.spageA-543, abstract T1691-
dc.identifier.epageA-543, abstract T1691en_HK
dc.publisher.placeUnited States-

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