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Conference Paper: Effects of hawthorn, a herbal medicine, on arterial blood pressure in anaesthetized rats

TitleEffects of hawthorn, a herbal medicine, on arterial blood pressure in anaesthetized rats
Authors
Issue Date2008
PublisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl
Citation
Experimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. 1S, p. 1129.17 How to Cite?
AbstractHawthorn is a herbal medicine that has been used to treat various cardiovascular disorders. It belongs to a member of the Rosaceae family and its major components include flavonoids and oligomeric procyanidin. The present study examined the cardiovascular effects of a commercial available hawthorn extract (WS 1442) in anaesthetized rats. The carotid artery was cannulated in anaesthetized rats for blood pressure and heart rate measurement. After bolus intravenous injections of WS 1442 (3.125, 6.25, 12.5 and 25 mg/kg), mean arterial blood pressure was reduced transiently in a dose-dependent manner. A greater effect on the diastolic than on the systolic blood pressure was observed. Heart rate was not significantly affected by all doses of WS 1442. Phenylephrine (1, 3 and 10 μg/kg) dose-dependently increased arterial blood pressure. Twenty minutes after the administration of the hawthorn extract (10 and 28 mg/kg/min for 7 min), the hypertensive actions of phenylephrine was significantly reduced when compared to rats without exposure to WS 1442. From these findings, it appears that the hawthorn extract possesses hypotensive action. Pre-exposure to the hawthorn extract also resulted in an impaired response to phenylephrine, suggesting that hawthorn may have a modulatory effect on blood pressure regulation. (Supported by a CRCG grant of HKU)
Persistent Identifierhttp://hdl.handle.net/10722/106748
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-25T23:28:48Z-
dc.date.available2010-09-25T23:28:48Z-
dc.date.issued2008en_HK
dc.identifier.citationExperimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. 1S, p. 1129.17-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/106748-
dc.description.abstractHawthorn is a herbal medicine that has been used to treat various cardiovascular disorders. It belongs to a member of the Rosaceae family and its major components include flavonoids and oligomeric procyanidin. The present study examined the cardiovascular effects of a commercial available hawthorn extract (WS 1442) in anaesthetized rats. The carotid artery was cannulated in anaesthetized rats for blood pressure and heart rate measurement. After bolus intravenous injections of WS 1442 (3.125, 6.25, 12.5 and 25 mg/kg), mean arterial blood pressure was reduced transiently in a dose-dependent manner. A greater effect on the diastolic than on the systolic blood pressure was observed. Heart rate was not significantly affected by all doses of WS 1442. Phenylephrine (1, 3 and 10 μg/kg) dose-dependently increased arterial blood pressure. Twenty minutes after the administration of the hawthorn extract (10 and 28 mg/kg/min for 7 min), the hypertensive actions of phenylephrine was significantly reduced when compared to rats without exposure to WS 1442. From these findings, it appears that the hawthorn extract possesses hypotensive action. Pre-exposure to the hawthorn extract also resulted in an impaired response to phenylephrine, suggesting that hawthorn may have a modulatory effect on blood pressure regulation. (Supported by a CRCG grant of HKU)-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtlen_HK
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleEffects of hawthorn, a herbal medicine, on arterial blood pressure in anaesthetized ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0176-8638&volume=&spage=&epage=&date=2008&atitle=Effects+of+hawthorn,+a+herbal+medicine,+on+arterial+blood+pressure+in+anaesthetized+ratsen_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.hkuros147367en_HK

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