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Conference Paper: Effect of flavonoids on cell proliferation: comparison with estrogen

TitleEffect of flavonoids on cell proliferation: comparison with estrogen
Authors
Issue Date2008
PublisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl
Citation
Experimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. 1S, p. 718.4 How to Cite?
AbstractSome flavonoids are structurally similar to 17β-estradiol and have been considered to be phytoestrogen or plant derived compounds with estrogenic actions. Our previous studies indicated that 17β-estradiol and certain flavonoids relaxed and favorably modulated vascular reactivity in porcine coronary arteries. These vascular actions of 17β-estradiol appeared to be mediated by receptors other than the classical estrogen receptors. In the present study, the potential of flavonoids to mimic the hormonal actions of 17β-estradiol were investigated. The effect of different flavonoids on the proliferation of the breast cancer cell line, MCF-7 cells, was examined by using the MTT assay. 17β-estradiol (10−6 M) significantly increased the rate of proliferation of MCF-7 cells, and this increase was inhibited by the classical estrogen receptor antagonist, ICI 182780 (10−9 M). None of the 13 different flavonoids tested, at concentrations ranging from 10−9 to 10−5 M, significantly affected the proliferation of MCF-7 cells. However, these flavonoids (10−9 to 10−6 M), except quercetin, inhibited the proliferating action of 17β-estradiol (10−6 M) on MCF-7 cells. These results suggested that flavonoids bind to the classical estrogen receptors without activating them. Thus flavonoids elicit similar vascular actions to 17β-estradiol but they do not induce the hormonal effects. (Supported by the Research Grant Council of Hong Kong)
Persistent Identifierhttp://hdl.handle.net/10722/106709
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorLeung, GPHen_HK
dc.date.accessioned2010-09-25T23:27:11Z-
dc.date.available2010-09-25T23:27:11Z-
dc.date.issued2008en_HK
dc.identifier.citationExperimental Biology 2008 - ASPET's Centennial Meeting, San Diego, CA, 5-9 April 2008. In The FASEB Journal, 2008, v. 22 n. 1S, p. 718.4-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/106709-
dc.description.abstractSome flavonoids are structurally similar to 17β-estradiol and have been considered to be phytoestrogen or plant derived compounds with estrogenic actions. Our previous studies indicated that 17β-estradiol and certain flavonoids relaxed and favorably modulated vascular reactivity in porcine coronary arteries. These vascular actions of 17β-estradiol appeared to be mediated by receptors other than the classical estrogen receptors. In the present study, the potential of flavonoids to mimic the hormonal actions of 17β-estradiol were investigated. The effect of different flavonoids on the proliferation of the breast cancer cell line, MCF-7 cells, was examined by using the MTT assay. 17β-estradiol (10−6 M) significantly increased the rate of proliferation of MCF-7 cells, and this increase was inhibited by the classical estrogen receptor antagonist, ICI 182780 (10−9 M). None of the 13 different flavonoids tested, at concentrations ranging from 10−9 to 10−5 M, significantly affected the proliferation of MCF-7 cells. However, these flavonoids (10−9 to 10−6 M), except quercetin, inhibited the proliferating action of 17β-estradiol (10−6 M) on MCF-7 cells. These results suggested that flavonoids bind to the classical estrogen receptors without activating them. Thus flavonoids elicit similar vascular actions to 17β-estradiol but they do not induce the hormonal effects. (Supported by the Research Grant Council of Hong Kong)-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtlen_HK
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleEffect of flavonoids on cell proliferation: comparison with estrogenen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0176-8638&volume=&spage=&epage=&date=2008&atitle=Effects+of+flavonoids+on+cell+proliferation:+comparison+with+estrogen+en_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailLeung, GPH: leung_pak_heng@hotmail.comen_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.identifier.hkuros147369en_HK

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