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Article: Nonprogressors of HIV infection: Hong Kong experience

TitleNonprogressors of HIV infection: Hong Kong experience
Authors
KeywordsHemophilia
HIV
Nonprogression
Issue Date1996
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijid
Citation
International Journal of Infectious Diseases, v. 1 n. 1, p. 14-17 How to Cite?
AbstractObjectives: The progression of human immunodeficiency virus (HIV) disease varies considerably among infected people, being affected by factors such as virus characteristics, host response, and their interactions. Some patients with HIV may remain clinically and immunologically well for an extended period. This study aims to describe the frequency and demographic features of a group of HIV-1 positive nonprogressors in Hong Kong. Method: A retrospective study was conducted of records of a cohort of 58 HIV-1 positive patients infected for over 7 years in Hong Kong. Nonprogression is defined as the maintenance of health with no symptoms and a CD4 level of 500/μL or higher. Results: Twenty-five patients had progressed to acquired immunodeficiency syndrome (22 died); 3 had had other HIV-related symptoms; 22 were asymptomatic but had CD4 lower than 500/μL; and 8 (13.8%) were nonprogressors with no symptoms and CD4 count higher than 500/μL (median of 665/μL an average of 102.5 months after HIV detection). The nonprogressors had a relatively high CD8 level. Hemophilia with transfusion of HIV-contaminated blood products accounted for 100% of all nonprogressors, and 58% of those with clinical or immunologic progression (P = 0.041). Conclusion: These findings indicate that a proportion of HIV-infected individuals do not progress clinically or immunologically over a prolonged period. To date, all nonprogressors known to the authors are patients with hemophilia.
Persistent Identifierhttp://hdl.handle.net/10722/106526
ISSN
2015 Impact Factor: 2.229
2015 SCImago Journal Rankings: 1.148
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KHen_HK
dc.contributor.authorLee, SSen_HK
dc.contributor.authorChoi, MYen_HK
dc.contributor.authorLee, CKen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-25T23:19:25Z-
dc.date.available2010-09-25T23:19:25Z-
dc.date.issued1996en_HK
dc.identifier.citationInternational Journal of Infectious Diseases, v. 1 n. 1, p. 14-17en_HK
dc.identifier.issn1201-9712en_HK
dc.identifier.urihttp://hdl.handle.net/10722/106526-
dc.description.abstractObjectives: The progression of human immunodeficiency virus (HIV) disease varies considerably among infected people, being affected by factors such as virus characteristics, host response, and their interactions. Some patients with HIV may remain clinically and immunologically well for an extended period. This study aims to describe the frequency and demographic features of a group of HIV-1 positive nonprogressors in Hong Kong. Method: A retrospective study was conducted of records of a cohort of 58 HIV-1 positive patients infected for over 7 years in Hong Kong. Nonprogression is defined as the maintenance of health with no symptoms and a CD4 level of 500/μL or higher. Results: Twenty-five patients had progressed to acquired immunodeficiency syndrome (22 died); 3 had had other HIV-related symptoms; 22 were asymptomatic but had CD4 lower than 500/μL; and 8 (13.8%) were nonprogressors with no symptoms and CD4 count higher than 500/μL (median of 665/μL an average of 102.5 months after HIV detection). The nonprogressors had a relatively high CD8 level. Hemophilia with transfusion of HIV-contaminated blood products accounted for 100% of all nonprogressors, and 58% of those with clinical or immunologic progression (P = 0.041). Conclusion: These findings indicate that a proportion of HIV-infected individuals do not progress clinically or immunologically over a prolonged period. To date, all nonprogressors known to the authors are patients with hemophilia.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijiden_HK
dc.relation.ispartofInternational Journal of Infectious Diseasesen_HK
dc.rightsInternational Journal of Infectious Diseases. Copyright © Elsevier Ltd.en_HK
dc.subjectHemophiliaen_HK
dc.subjectHIVen_HK
dc.subjectNonprogressionen_HK
dc.titleNonprogressors of HIV infection: Hong Kong experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1201-9712&volume=1&issue=1&spage=14&epage=17&date=1995&atitle=Nonprogressors+of+HIV+infection:+Hong+Kong+experienceen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0010244289en_HK
dc.identifier.hkuros11487en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0010244289&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue1en_HK
dc.identifier.spage14en_HK
dc.identifier.epage17en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, KH=7404758411en_HK
dc.identifier.scopusauthoridLee, SS=7601394467en_HK
dc.identifier.scopusauthoridChoi, MY=35733368100en_HK
dc.identifier.scopusauthoridLee, CK=7410162028en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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