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Conference Paper: Early age-dependent growth impairment in chronic renal failure

TitleEarly age-dependent growth impairment in chronic renal failure
Authors
Issue Date1996
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
Citation
Pediatric Nephrology, v. 10, p. 283-287 How to Cite?
AbstractWe report early linear growth in 73 children (51 boys, 22 girls) with early onset of chronic renal failure (CRF). The inclusion criteria was onset of CRF before 6 months of age, two or more height measurements during the 1st year of life, follow-up for at least 3 years and continuously impaired renal function with a glomerular filtration rate below 50 ml/min per 1.73 m 2 at 1 year or later. Only height measurements taken during conservative treatment or dialysis were included. The data were analysed in terms of the infancy-childhood-puberty growth model. There was an age-dependent growth failure in early life leading to an attained height of -3 standard deviation score (SDS) at 3 years of age. Approximately one-third of the reduction in height occurred during fetal life and one-third during the first postnatal months. Between 0.75 and 1.5 years of age height also decreased by 1 SD as a consequence of a delayed onset of the second, the 'childhood', phase of growth in 36% of the patients and by an 'offset childhood' growth pattern - i.e. a return to the infancy phase pattern after onset of the childhood phase - in 60% of the patients. Growth between 0.25-0.75 and 1.5-5 years of age was generally percentile parallel and thus less likely to be affected in CRF with early disease onset. The glomerular filtration rate was not related to the height gain in early life. We speculate that the growth failure during fetal life and the first postnatal months reflects metabolic and/or nutritional influences and the impaired growth at 0.75-1.5 years of age is related to a partial insensitivity to growth hormone.
Persistent Identifierhttp://hdl.handle.net/10722/106159
ISSN
2015 Impact Factor: 2.338
2015 SCImago Journal Rankings: 0.959
References

 

DC FieldValueLanguage
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorSchaefer, Fen_HK
dc.contributor.authorHennicke, Men_HK
dc.contributor.authorWingen, AMen_HK
dc.contributor.authorRigden, Sen_HK
dc.contributor.authorMehls, Oen_HK
dc.contributor.authorRätch, Ien_HK
dc.contributor.authorMichelis, Ken_HK
dc.contributor.authorKapogiannis, Ten_HK
dc.contributor.authorJung, Fen_HK
dc.contributor.authorLennert, Ten_HK
dc.contributor.authorGellert, Sen_HK
dc.contributor.authorTulassay, Ten_HK
dc.contributor.authorSallay, Pen_HK
dc.contributor.authorVon Lilien, Ten_HK
dc.contributor.authorMichalk, Den_HK
dc.contributor.authorVon WendtGöknur, MAen_HK
dc.contributor.authorBonzel, KEen_HK
dc.contributor.authorGusmano, Ren_HK
dc.contributor.authorVerrina, Een_HK
dc.contributor.authorOffner, Gen_HK
dc.contributor.authorMehls, Oen_HK
dc.contributor.authorWingen, AMen_HK
dc.contributor.authorFabianBach, Cen_HK
dc.contributor.authorAppiani, Aen_HK
dc.contributor.authorBettinelli, Aen_HK
dc.contributor.authorFeber, Jen_HK
dc.contributor.authorRizzoni, Gen_HK
dc.contributor.authorPicca, Sen_HK
dc.contributor.authorStolpe, HJen_HK
dc.contributor.authorWigger, Men_HK
dc.contributor.authorKistvan Holthe, Jen_HK
dc.contributor.authorWolff, Een_HK
dc.contributor.authorBerg, Uen_HK
dc.contributor.authorFischbach, Men_HK
dc.contributor.authorDobos, Een_HK
dc.contributor.authorBalzar, Een_HK
dc.contributor.authorNeuhaus, Ten_HK
dc.date.accessioned2010-09-25T23:04:04Z-
dc.date.available2010-09-25T23:04:04Z-
dc.date.issued1996en_HK
dc.identifier.citationPediatric Nephrology, v. 10, p. 283-287en_HK
dc.identifier.issn0931-041Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/106159-
dc.description.abstractWe report early linear growth in 73 children (51 boys, 22 girls) with early onset of chronic renal failure (CRF). The inclusion criteria was onset of CRF before 6 months of age, two or more height measurements during the 1st year of life, follow-up for at least 3 years and continuously impaired renal function with a glomerular filtration rate below 50 ml/min per 1.73 m 2 at 1 year or later. Only height measurements taken during conservative treatment or dialysis were included. The data were analysed in terms of the infancy-childhood-puberty growth model. There was an age-dependent growth failure in early life leading to an attained height of -3 standard deviation score (SDS) at 3 years of age. Approximately one-third of the reduction in height occurred during fetal life and one-third during the first postnatal months. Between 0.75 and 1.5 years of age height also decreased by 1 SD as a consequence of a delayed onset of the second, the 'childhood', phase of growth in 36% of the patients and by an 'offset childhood' growth pattern - i.e. a return to the infancy phase pattern after onset of the childhood phase - in 60% of the patients. Growth between 0.25-0.75 and 1.5-5 years of age was generally percentile parallel and thus less likely to be affected in CRF with early disease onset. The glomerular filtration rate was not related to the height gain in early life. We speculate that the growth failure during fetal life and the first postnatal months reflects metabolic and/or nutritional influences and the impaired growth at 0.75-1.5 years of age is related to a partial insensitivity to growth hormone.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htmen_HK
dc.relation.ispartofPediatric Nephrologyen_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGrowth - physiologyen_HK
dc.subject.meshGrowth Disorders - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshKidney Failure, Chronic - complicationsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titleEarly age-dependent growth impairment in chronic renal failureen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0931-041X&volume=10&spage=283&epage=287&date=1995&atitle=Early+age-dependent+growth+impairment+in+chronic+renal+failureen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s004670050110en_HK
dc.identifier.pmid8792391-
dc.identifier.scopuseid_2-s2.0-9344257303en_HK
dc.identifier.hkuros15175en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9344257303&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue3en_HK
dc.identifier.spage283en_HK
dc.identifier.epage287en_HK
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridSchaefer, F=7103383884en_HK
dc.identifier.scopusauthoridHennicke, M=16749882200en_HK
dc.identifier.scopusauthoridWingen, AM=7003847740en_HK
dc.identifier.scopusauthoridRigden, S=7007054467en_HK
dc.identifier.scopusauthoridMehls, O=7103033918en_HK
dc.identifier.scopusauthoridRätch, I=6504124249en_HK
dc.identifier.scopusauthoridMichelis, K=6603282022en_HK
dc.identifier.scopusauthoridKapogiannis, T=6507427172en_HK
dc.identifier.scopusauthoridJung, F=7202051942en_HK
dc.identifier.scopusauthoridLennert, T=6701718836en_HK
dc.identifier.scopusauthoridGellert, S=6603856143en_HK
dc.identifier.scopusauthoridTulassay, T=7006062180en_HK
dc.identifier.scopusauthoridSallay, P=36887792000en_HK
dc.identifier.scopusauthoridVon Lilien, T=6603318504en_HK
dc.identifier.scopusauthoridMichalk, D=7006004044en_HK
dc.identifier.scopusauthoridVon WendtGöknur, MA=6505831512en_HK
dc.identifier.scopusauthoridBonzel, KE=7003275905en_HK
dc.identifier.scopusauthoridGusmano, R=7006299263en_HK
dc.identifier.scopusauthoridVerrina, E=7004630726en_HK
dc.identifier.scopusauthoridOffner, G=7006455951en_HK
dc.identifier.scopusauthoridMehls, O=16943606800en_HK
dc.identifier.scopusauthoridWingen, AM=7003847733en_HK
dc.identifier.scopusauthoridFabianBach, C=6506084918en_HK
dc.identifier.scopusauthoridAppiani, A=6602132359en_HK
dc.identifier.scopusauthoridBettinelli, A=7005956711en_HK
dc.identifier.scopusauthoridFeber, J=7004248589en_HK
dc.identifier.scopusauthoridRizzoni, G=7103076722en_HK
dc.identifier.scopusauthoridPicca, S=6701341737en_HK
dc.identifier.scopusauthoridStolpe, HJ=7004888410en_HK
dc.identifier.scopusauthoridWigger, M=7003547585en_HK
dc.identifier.scopusauthoridKistvan Holthe, J=6701824029en_HK
dc.identifier.scopusauthoridWolff, E=35578354800en_HK
dc.identifier.scopusauthoridBerg, U=7101908773en_HK
dc.identifier.scopusauthoridFischbach, M=7102623870en_HK
dc.identifier.scopusauthoridDobos, E=6602842231en_HK
dc.identifier.scopusauthoridBalzar, E=7006223700en_HK
dc.identifier.scopusauthoridNeuhaus, T=7005048567en_HK

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