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Conference Paper: Calcium channel blockers can reduce iron-induced apoptosis in neuroal stem cells

TitleCalcium channel blockers can reduce iron-induced apoptosis in neuroal stem cells
Authors
KeywordsMedical sciences
Issue Date2009
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 1st Hong Kong Neurological Congress cum 22nd Annual Scientific Meeting of The Hong Kong Neurological Society (HKNS 2009), Hong Kong, 6-8 November 2009. In Hong Kong Medical Journal, 2009, v. 15 suppl. 7, p. 45, abstract no. P11 How to Cite?
AbstractExcessive iron accumulation in the brain with oxidative damage has commonly been observed in haemorrhagic stroke as well as neurodegenerative disorders. It is partly mediated via extracellular signal–regulated kinases (ERK) signalling cascades that regulate a diverse neuronal functional processes including cell death. Since L-type calcium channels are key passages responsible for the iron entry into neuronal cells and therefore we postulated its blocker, nimodipine and flunarizine, could potentially protect against iron-induced neurotoxicity in neural stem cells (NSCs). In-vitro studies of iron overload on murine-derived multipotent neural stem cell line C17.2 cells and rat embryonic (E13.5) hippocampal neural stem cells (hNSCs) were performed. The cytotoxic effect of various forms of iron compound ...
DescriptionPoster: no. P11
Persistent Identifierhttp://hdl.handle.net/10722/105989
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChen, Wen_HK
dc.contributor.authorWong, VCNen_HK
dc.contributor.authorYang, Men_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-25T22:56:59Z-
dc.date.available2010-09-25T22:56:59Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 1st Hong Kong Neurological Congress cum 22nd Annual Scientific Meeting of The Hong Kong Neurological Society (HKNS 2009), Hong Kong, 6-8 November 2009. In Hong Kong Medical Journal, 2009, v. 15 suppl. 7, p. 45, abstract no. P11-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/105989-
dc.descriptionPoster: no. P11-
dc.description.abstractExcessive iron accumulation in the brain with oxidative damage has commonly been observed in haemorrhagic stroke as well as neurodegenerative disorders. It is partly mediated via extracellular signal–regulated kinases (ERK) signalling cascades that regulate a diverse neuronal functional processes including cell death. Since L-type calcium channels are key passages responsible for the iron entry into neuronal cells and therefore we postulated its blocker, nimodipine and flunarizine, could potentially protect against iron-induced neurotoxicity in neural stem cells (NSCs). In-vitro studies of iron overload on murine-derived multipotent neural stem cell line C17.2 cells and rat embryonic (E13.5) hippocampal neural stem cells (hNSCs) were performed. The cytotoxic effect of various forms of iron compound ...-
dc.languageengen_HK
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.titleCalcium channel blockers can reduce iron-induced apoptosis in neuroal stem cellsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWong, VCN: vcnwong@hku.hken_HK
dc.identifier.emailYang, M: yangm1091@yahoo.com.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hku.hken_HK
dc.identifier.authorityWong, VCN=rp00334en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros168169en_HK
dc.identifier.volume15-
dc.identifier.issuesuppl. 7-
dc.identifier.spage45-
dc.identifier.epage45-
dc.publisher.placeHong Kong-
dc.customcontrol.immutablesml 140711-

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