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Conference Paper: The Efficacy of the Clonidine Stimulation Test

TitleThe Efficacy of the Clonidine Stimulation Test
Authors
Issue Date1996
PublisherMedcom Limited.
Citation
The 1st Joint Scientific Meeting of Hong Kong College of Paediatricians and Guangdong Pediatric Society of the Chinese Medical Association, Guangzhou, China, 25 May 1996. In Hong Kong Journal of Paediatrics, 1996, v.1 n. 2, p. 204 How to Cite?
AbstractObjective To review the efficacy of the clonidine stimulation test as a screening test for growth hormone deficiency (GHD) in children with short stature. Method This is a retrospective review of 86 short children tested for growth hormone (GH) secretion using the clonidine stimulation test. Clonidine at a dosage of 0.1 mg/m2 was given orally after an overnight fast. Blood samples for GH levels were taken from an indwelling catheter at 30, 60, 90 and 120 minutes after medication. Children were recumbent during the test and blood pressure was monitored every 30 minutes. A peak GH response of less than 15 mIU/L was considered abnormal. These children were then subjected to a confirmatory test with insulin induced hypoglycaemia (ITT). The sensitivity and specificity of the test and its side effects were analysed. Results Of the 86 children, 37 were females and 49 were males. The mean age was 9.59±2.99 years (range: 2.08-16.50 years). Sixty children passed while 26 children failed the test. Of those who failed, 9 were diagnosed as having GHD by failing two tests while 17 (22.1%) subsequently had normal GH response to ITT (low-responders). Twenty-four children (27.9%) had significant drop in the systolic blood pressure of >20 mmHg but only 4 (4.7%) of them complained of dizziness. 88.3% of the peak GH response occurred at 60 and 90 minutes. No patient and 3 patients with adequate GH response will be missed if the 30 min and 120 min samples were omitted respectively. The mean peak GH for the GHD patients and the low-responders were 8.05±4.61 mIU/L and 8.89±4.28 mIU/L respectively (p>0.05). Conclusion The clonidine stimulation test has a specificity of 77.9% and a positive predictive value of 34.6%. The false positive rate is 22.1% which is much higher than the 12.5% obtained for L-dopa-propanolol test according to our own experience.1 The 30 min sample can be omitted without significant effect. The high false positive rate, the significant drop in systolic blood pressure, the close monitoring and the greater number of samples required for the clonidine stimulation test make the Irdopa the preferable test for screening for growth hormone deficiency. 1J Paediatr Child Health 1994;30:328-30.
Persistent Identifierhttp://hdl.handle.net/10722/105917
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorKwan, EYWen_HK
dc.contributor.authorCheung, PTen_HK
dc.contributor.authorLow, LCKen_HK
dc.date.accessioned2010-09-25T22:54:01Z-
dc.date.available2010-09-25T22:54:01Z-
dc.date.issued1996en_HK
dc.identifier.citationThe 1st Joint Scientific Meeting of Hong Kong College of Paediatricians and Guangdong Pediatric Society of the Chinese Medical Association, Guangzhou, China, 25 May 1996. In Hong Kong Journal of Paediatrics, 1996, v.1 n. 2, p. 204en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105917-
dc.description.abstractObjective To review the efficacy of the clonidine stimulation test as a screening test for growth hormone deficiency (GHD) in children with short stature. Method This is a retrospective review of 86 short children tested for growth hormone (GH) secretion using the clonidine stimulation test. Clonidine at a dosage of 0.1 mg/m2 was given orally after an overnight fast. Blood samples for GH levels were taken from an indwelling catheter at 30, 60, 90 and 120 minutes after medication. Children were recumbent during the test and blood pressure was monitored every 30 minutes. A peak GH response of less than 15 mIU/L was considered abnormal. These children were then subjected to a confirmatory test with insulin induced hypoglycaemia (ITT). The sensitivity and specificity of the test and its side effects were analysed. Results Of the 86 children, 37 were females and 49 were males. The mean age was 9.59±2.99 years (range: 2.08-16.50 years). Sixty children passed while 26 children failed the test. Of those who failed, 9 were diagnosed as having GHD by failing two tests while 17 (22.1%) subsequently had normal GH response to ITT (low-responders). Twenty-four children (27.9%) had significant drop in the systolic blood pressure of >20 mmHg but only 4 (4.7%) of them complained of dizziness. 88.3% of the peak GH response occurred at 60 and 90 minutes. No patient and 3 patients with adequate GH response will be missed if the 30 min and 120 min samples were omitted respectively. The mean peak GH for the GHD patients and the low-responders were 8.05±4.61 mIU/L and 8.89±4.28 mIU/L respectively (p>0.05). Conclusion The clonidine stimulation test has a specificity of 77.9% and a positive predictive value of 34.6%. The false positive rate is 22.1% which is much higher than the 12.5% obtained for L-dopa-propanolol test according to our own experience.1 The 30 min sample can be omitted without significant effect. The high false positive rate, the significant drop in systolic blood pressure, the close monitoring and the greater number of samples required for the clonidine stimulation test make the Irdopa the preferable test for screening for growth hormone deficiency. 1J Paediatr Child Health 1994;30:328-30.-
dc.languageengen_HK
dc.publisherMedcom Limited.en_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.titleThe Efficacy of the Clonidine Stimulation Testen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=1 &issue=No. 2&spage=204&epage=&date=1996&atitle=The+Efficacy+of+the+Clonidine+Stimulation+Testen_HK
dc.identifier.emailKwan, EYW: eywkwan@hkucc.hku.hken_HK
dc.identifier.emailCheung, PT: ptcheung@hkucc.hku.hken_HK
dc.identifier.emailLow, LCK: lcklow@hkucc.hku.hken_HK
dc.identifier.authorityCheung, PT=rp00351en_HK
dc.identifier.authorityLow, LCK=rp00337en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros22427en_HK
dc.identifier.volume1en_HK
dc.identifier.issue2en_HK
dc.identifier.spage204en_HK

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