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Conference Paper: Cyclooxygenase-2 Expression in Nasopharyngeal Carcinoma

TitleCyclooxygenase-2 Expression in Nasopharyngeal Carcinoma
Authors
Issue Date2007
PublisherElsevier Inc.
Citation
American Society for Therapeutic Radiology and Oncology 49th Annual Meeting, Los Angeles, CA, 28 October–1 November 2007. In International Journal of Radiation: Oncology - Biology - Physics, 2007, v. 69 n. 1 3S, p. S440 Abstract no. 2427 How to Cite?
AbstractPurpose/Objective(s): Cyclooxygenase-2 (COX-2) expression in tumor and epithelium was evaluated before and during radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Materials/Methods: 53 patients (36 males and 17 females) with NPC had tumor biopsy performed before RT. Except for 1 well differentiated squamous cell carcinoma (1.9%), all others were poorly differentiated or undifferentiated carcinoma (98.1%). Neighboring non-malignant epithelium was found in 43 of the pre-RT biopsies. 43 patients had another NP biopsy after 2–3 weeks of RT but 14 did not have tumor in the second biopsy. Normal epithelium was assessable in 39 of the second biopsy. The intensity and extent of COX-2 expression in tumor and epithelium were evaluated with immunohistochemical staining. Results: The number of patients with stage I, II, III and IV disease were 6, 15, 13 and 19, respectively. All patients had RT, 24 patients also had cisplatin concurrent with RT. For the pre-RT biopsies, only 7.5% tumors showed no COX-2 expression compared with 65.1% of epithelium. 28.3% of tumor had no to mild COX-2 staining compared with 83.7% in neighboring epithelium. 71.7% of tumor had moderate to intense COX-2 staining compared with 16.3% in the epithelium. The 3 epithelium which showed intense staining for COX-2 were all dysplastic. There was similar difference in the extent of COX-2 staining between tumor and the epithelium. 37.7% of tumor showed\10% positive staining compared with 90.7% of epithelium. 62.3% of tumor showed at least 10% positive staining compared with 9.3% in epithelium. After 2–3 weeks of RT/chemoRT, 32.6% of the repeat biopsies showed no tumor. Of the 29 biopsies that had tumor cells, the intensity of COX-2 staining in tumor cells remained unchanged in 37.9%, decreased in 34.5% and increased in 27.6%, compared with their pre-RT biopsies. Similarly, the extent of COX-2 staining in tumor showed no change in 48.3%, decreased in 34.5% and increased in 17.2% in the second biopsy. 32 patients had assessable epithelium in both biopsies. Compared with the pre-RT biopsy, there was no change in intensity and extent of COX-2 staining in the epithelium in 43.8%, increased in 28.1% and decreased in 28.1% of the second biopsies. There was no correlation between COX-2 expression in tumor with stage or outcome after treatment (Table). Conclusions: COX-2 overexpression was commonly observed in NPC but not in neighboring non-malignant epithelium. After 2– 3 weeks of RT, 32.6% of biopsy turned negative and another 34.5% of tumor showed reduced COX-2 expression. The intensity and extent of COX-2 staining in tumor and neighboring non-malignant epithelium before and after 2 to 3 weeks of RT.
Persistent Identifierhttp://hdl.handle.net/10722/105592
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274

 

DC FieldValueLanguage
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorNicholls, J-
dc.contributor.authorSham, J-
dc.date.accessioned2010-09-25T22:40:35Z-
dc.date.available2010-09-25T22:40:35Z-
dc.date.issued2007en_HK
dc.identifier.citationAmerican Society for Therapeutic Radiology and Oncology 49th Annual Meeting, Los Angeles, CA, 28 October–1 November 2007. In International Journal of Radiation: Oncology - Biology - Physics, 2007, v. 69 n. 1 3S, p. S440 Abstract no. 2427-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/105592-
dc.description.abstractPurpose/Objective(s): Cyclooxygenase-2 (COX-2) expression in tumor and epithelium was evaluated before and during radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Materials/Methods: 53 patients (36 males and 17 females) with NPC had tumor biopsy performed before RT. Except for 1 well differentiated squamous cell carcinoma (1.9%), all others were poorly differentiated or undifferentiated carcinoma (98.1%). Neighboring non-malignant epithelium was found in 43 of the pre-RT biopsies. 43 patients had another NP biopsy after 2–3 weeks of RT but 14 did not have tumor in the second biopsy. Normal epithelium was assessable in 39 of the second biopsy. The intensity and extent of COX-2 expression in tumor and epithelium were evaluated with immunohistochemical staining. Results: The number of patients with stage I, II, III and IV disease were 6, 15, 13 and 19, respectively. All patients had RT, 24 patients also had cisplatin concurrent with RT. For the pre-RT biopsies, only 7.5% tumors showed no COX-2 expression compared with 65.1% of epithelium. 28.3% of tumor had no to mild COX-2 staining compared with 83.7% in neighboring epithelium. 71.7% of tumor had moderate to intense COX-2 staining compared with 16.3% in the epithelium. The 3 epithelium which showed intense staining for COX-2 were all dysplastic. There was similar difference in the extent of COX-2 staining between tumor and the epithelium. 37.7% of tumor showed\10% positive staining compared with 90.7% of epithelium. 62.3% of tumor showed at least 10% positive staining compared with 9.3% in epithelium. After 2–3 weeks of RT/chemoRT, 32.6% of the repeat biopsies showed no tumor. Of the 29 biopsies that had tumor cells, the intensity of COX-2 staining in tumor cells remained unchanged in 37.9%, decreased in 34.5% and increased in 27.6%, compared with their pre-RT biopsies. Similarly, the extent of COX-2 staining in tumor showed no change in 48.3%, decreased in 34.5% and increased in 17.2% in the second biopsy. 32 patients had assessable epithelium in both biopsies. Compared with the pre-RT biopsy, there was no change in intensity and extent of COX-2 staining in the epithelium in 43.8%, increased in 28.1% and decreased in 28.1% of the second biopsies. There was no correlation between COX-2 expression in tumor with stage or outcome after treatment (Table). Conclusions: COX-2 overexpression was commonly observed in NPC but not in neighboring non-malignant epithelium. After 2– 3 weeks of RT, 32.6% of biopsy turned negative and another 34.5% of tumor showed reduced COX-2 expression. The intensity and extent of COX-2 staining in tumor and neighboring non-malignant epithelium before and after 2 to 3 weeks of RT.-
dc.languageengen_HK
dc.publisherElsevier Inc.-
dc.relation.ispartofInternational Journal of Radiation: Oncology - Biology - Physicsen_HK
dc.titleCyclooxygenase-2 Expression in Nasopharyngeal Carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2007.07.1603-
dc.identifier.hkuros151816en_HK

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