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Conference Paper: Diffusion-Tensor MR Imaging in the Evaluation of Treatment-Induced Neurotoxicity in Medulloblastoma Survivors

TitleDiffusion-Tensor MR Imaging in the Evaluation of Treatment-Induced Neurotoxicity in Medulloblastoma Survivors
Authors
Issue Date2003
PublisherInternational Society for Magnetic Resonance in Medicine (ISMRM)
Citation
International Society for Magnetic Resonance in Medicine (ISMRM) 11th Scientific Meeting & Exhibition, Toronto, Canada, 10-16 July 2003 How to Cite?
AbstractWe use DTI to evaluate treatment-induced neurotoxicity in medulloblastoma survivors. Fractional anisotropy (FA) of supratentorial white matter (WM) in thirteen medulloblastoma survivors was measured and compared to healthy age-matched controls. Reduction in FA was compared with deterioration in school performance. FA of patients was reduced compared to controls and this was statistically significant in the parietal WM and corona radiata (p=0.011 and p=0.040 respectively). FA reduction was greater in children with moderate/severe, compared to those with mild deterioration in school performance (60.6% and 19.9% respectively, p=0.041). DTI, using FA, is useful in the detection and monitoring of treatment-induced neurotoxicity.
Persistent Identifierhttp://hdl.handle.net/10722/105589
ISSN

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorChan, FLen_HK
dc.date.accessioned2010-09-25T22:40:27Z-
dc.date.available2010-09-25T22:40:27Z-
dc.date.issued2003en_HK
dc.identifier.citationInternational Society for Magnetic Resonance in Medicine (ISMRM) 11th Scientific Meeting & Exhibition, Toronto, Canada, 10-16 July 2003-
dc.identifier.issn1545-4428-
dc.identifier.urihttp://hdl.handle.net/10722/105589-
dc.description.abstractWe use DTI to evaluate treatment-induced neurotoxicity in medulloblastoma survivors. Fractional anisotropy (FA) of supratentorial white matter (WM) in thirteen medulloblastoma survivors was measured and compared to healthy age-matched controls. Reduction in FA was compared with deterioration in school performance. FA of patients was reduced compared to controls and this was statistically significant in the parietal WM and corona radiata (p=0.011 and p=0.040 respectively). FA reduction was greater in children with moderate/severe, compared to those with mild deterioration in school performance (60.6% and 19.9% respectively, p=0.041). DTI, using FA, is useful in the detection and monitoring of treatment-induced neurotoxicity.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine (ISMRM)-
dc.relation.ispartofInternational Society for Magnetic Resonance in Medicine (ISMRM) Scientific Meeting & Exhibitionen_HK
dc.titleDiffusion-Tensor MR Imaging in the Evaluation of Treatment-Induced Neurotoxicity in Medulloblastoma Survivorsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hkucc.hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.hkuros87810en_HK

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