File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Brain Sources for change-detection: an ERP study in patients at the outbreak of early onset schizophrenia and 15 years later

TitleBrain Sources for change-detection: an ERP study in patients at the outbreak of early onset schizophrenia and 15 years later
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 129, abstract no. 241 How to Cite?
AbstractBACKGROUND: Severer illness, poorer prognosis and impaired brain structure are reported for patients with an early-onset of schizophrenia1,2. Is this reflected in early stimulus processing? METHODS: This study compares an electrophysiological measure of automatic, auditory attention-related function and its sources in the brain for 19 patients (17.5 years) at onset, and 17 patients 15 years after an early onset with age-matched healthy subjects. RESULTS: Mismatch Negativity (MMN), recorded from 32 sites during a simple visual vigilance task, was associated with a rare tone shorter than the standard. Brain electrical source analysis (BESA) confirmed bilateral frontal and temporal lobe dipoles3. Both patient groups showed a smaller MMN than the controls. There were several signs of illness progression in the older patient group: (a) a visual vigilance decrement was only evident in the older patients, (b) the left superior temporal source was weaker, (c) the left cingulate source changed orientation, (d) the right inferior/mid-frontal source was active later. This illness-related progression of a cognitive impairment is consistent with a neurodevelopmental hypothesis4, initial structural impairments in young patients5 contrasting with more variable or sporadic changes in those with a later onset6,7.
Persistent Identifierhttp://hdl.handle.net/10722/105517
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorJuran, Sen_HK
dc.contributor.authorOknina, Len_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorTorres, Ren_HK
dc.contributor.authorHerwig, Ken_HK
dc.contributor.authorWeissbrod, Men_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorRoepcke, Ben_HK
dc.date.accessioned2010-09-25T22:37:24Z-
dc.date.available2010-09-25T22:37:24Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 129, abstract no. 241en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105517-
dc.description.abstractBACKGROUND: Severer illness, poorer prognosis and impaired brain structure are reported for patients with an early-onset of schizophrenia1,2. Is this reflected in early stimulus processing? METHODS: This study compares an electrophysiological measure of automatic, auditory attention-related function and its sources in the brain for 19 patients (17.5 years) at onset, and 17 patients 15 years after an early onset with age-matched healthy subjects. RESULTS: Mismatch Negativity (MMN), recorded from 32 sites during a simple visual vigilance task, was associated with a rare tone shorter than the standard. Brain electrical source analysis (BESA) confirmed bilateral frontal and temporal lobe dipoles3. Both patient groups showed a smaller MMN than the controls. There were several signs of illness progression in the older patient group: (a) a visual vigilance decrement was only evident in the older patients, (b) the left superior temporal source was weaker, (c) the left cingulate source changed orientation, (d) the right inferior/mid-frontal source was active later. This illness-related progression of a cognitive impairment is consistent with a neurodevelopmental hypothesis4, initial structural impairments in young patients5 contrasting with more variable or sporadic changes in those with a later onset6,7.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleBrain Sources for change-detection: an ERP study in patients at the outbreak of early onset schizophrenia and 15 years lateren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67/1S&spage=129&epage=&date=2004&atitle=Brain++Sources+for+change-detection:+an+ERP+study+in+patients+at+the+outbreak+of+early+onset+schizophrenia+and+15+years+lateren_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.doihttp://dx.doi.org/10.1016/j.schres.2003.10.001-
dc.identifier.hkuros88269en_HK
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.-
dc.identifier.spage129, abstract no. 241en_HK
dc.identifier.epage129, abstract no. 241-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats