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Conference Paper: Treatment response and its correlates with cognitive functions in first-episode psychosis

TitleTreatment response and its correlates with cognitive functions in first-episode psychosis
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 122, abstract A253 How to Cite?
AbstractThis study aims to explore the relationship between treatment response and cognitive function in the first 20 months of a psychosis. A total of 153 patients (69 males, 84 females) experiencing first-episode psychosis were recruited and tested with a set of neurocognitive tasks upon admission, discharge, and every 4 months up to 20 months thereafter. Neurocognitive domains included attention (Continuous Performance Test), memory (Logical Memory Test, Visual Reproduction, and Digit Forward Span), and executive function (Verbal Fluency Test and Wisconsin Card Sorting Test). Treatment response was determined by the scores of positive and negative symptoms rated with the Positive and Negative Syndrome Scales by their clinicians at discharge. For each group of symptoms, two groups of patients were identified. Patients with no item scored higher than 2 fell into the remission group (RG), and those had at least one item scored 4 or higher went to the treatment resistant group (TRG).. Performance on the neurocognitive tests of the two groups was compared. Results showed that the TRG, no matter classified by positive symptoms (n = 27) or negative symptoms (n = 34), performed consistently more poorly than the RG (by positive symptoms, n = 92; by negative symptoms, ns64. in all cognitive domains at each time point. The difference was more profound for groups classified by negative symptoms. The results suggest that treatment response, especially that in negative symptoms, may be related to cognitive impairment in psychosis.
Persistent Identifierhttp://hdl.handle.net/10722/105508
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorTso, Fen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChung, KFen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorMiao, YKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorTang, OWNen_HK
dc.date.accessioned2010-09-25T22:37:02Z-
dc.date.available2010-09-25T22:37:02Z-
dc.date.issued2002en_HK
dc.identifier.citationThe 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 122, abstract A253en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105508-
dc.description.abstractThis study aims to explore the relationship between treatment response and cognitive function in the first 20 months of a psychosis. A total of 153 patients (69 males, 84 females) experiencing first-episode psychosis were recruited and tested with a set of neurocognitive tasks upon admission, discharge, and every 4 months up to 20 months thereafter. Neurocognitive domains included attention (Continuous Performance Test), memory (Logical Memory Test, Visual Reproduction, and Digit Forward Span), and executive function (Verbal Fluency Test and Wisconsin Card Sorting Test). Treatment response was determined by the scores of positive and negative symptoms rated with the Positive and Negative Syndrome Scales by their clinicians at discharge. For each group of symptoms, two groups of patients were identified. Patients with no item scored higher than 2 fell into the remission group (RG), and those had at least one item scored 4 or higher went to the treatment resistant group (TRG).. Performance on the neurocognitive tests of the two groups was compared. Results showed that the TRG, no matter classified by positive symptoms (n = 27) or negative symptoms (n = 34), performed consistently more poorly than the RG (by positive symptoms, n = 92; by negative symptoms, ns64. in all cognitive domains at each time point. The difference was more profound for groups classified by negative symptoms. The results suggest that treatment response, especially that in negative symptoms, may be related to cognitive impairment in psychosis.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleTreatment response and its correlates with cognitive functions in first-episode psychosisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=53&issue=3&spage=122&epage=&date=2002&atitle=Treatment+response+and+its+correlates+with+cognitive+functions+in+first-episode+psychosisen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.emailDunn, ELW: dunnlw@ha.org.hken_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailChung, KF: kfchung@hkucc.hku.hken_HK
dc.identifier.emailChan, WF: chanwf@ha.org.hken_HK
dc.identifier.emailTang, OWN: wntang@ha.org.hken_HK
dc.identifier.authorityChung, KF=rp00377en_HK
dc.identifier.doi10.1016/S0920-9964(01)00381-4-
dc.identifier.hkuros73397en_HK
dc.identifier.volume53en_HK
dc.identifier.issue3 suppl. 1en_HK
dc.identifier.spage122, abstract A253en_HK
dc.identifier.epage122, abstract A253-

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