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Conference Paper: Early evidence of cerebral grey matter volume changed after treatment in neuroleptic naïve, newly diagnosed schizophrenia

TitleEarly evidence of cerebral grey matter volume changed after treatment in neuroleptic naïve, newly diagnosed schizophrenia
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Montreux, Switzerland, 3-7 February 2008. In Schizophrenia Research, 2008, v. 98 suppl., p. 38 How to Cite?
AbstractBackground: Antipsychotic drugs influence brain morphology in schizophrenia and usually require 3 weeks for marked effect. We used a comprehensive computational morphometry analysis to investigate brain volumetric changes after 3 weeks of antipsychotic exposure in a prospective, longitudinal, cohort of anti-psychotic-naïve individuals newly diagnosed with schizophrenia. Methods: Voxel-based morphometric (VBM) analysis was performed on magnetic resonance images (MRI) of the brain acquired before (t = 0) and after 3 weeks (t = 3 weeks) of antipsychotic treatment in 17 individuals with first-episode schizophrenia who had never received anti-psychotic treatment (7 males, 10 females). SPM (Statistical Parametric Mapping) 99 software using paired t test s was used to perform VBM analysis of greymatter volumetric differences between t = 0 and t = 3 weeks. Results:After 3 weeks of antipsychotic medication, significant clusters of volume excess in greymatter were detected in bilateral caudate, right parahippocampal gyrus and right postcentral gyrus. Clusters of volume deficits were detected in left superior frontal gyrus. Region-of-interest (ROI) confirmed caudate volumetric increased afterearly medication. Conclusions: Brain volumetric changes after 3 weeks medication suggests that drug-mediated neural and brain plasticity may occur during clinical recovery.
Persistent Identifierhttp://hdl.handle.net/10722/105505
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorDeng, Yen_HK
dc.contributor.authorMerali, HSen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-25T22:36:54Z-
dc.date.available2010-09-25T22:36:54Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders, Montreux, Switzerland, 3-7 February 2008. In Schizophrenia Research, 2008, v. 98 suppl., p. 38en_HK
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/105505-
dc.description.abstractBackground: Antipsychotic drugs influence brain morphology in schizophrenia and usually require 3 weeks for marked effect. We used a comprehensive computational morphometry analysis to investigate brain volumetric changes after 3 weeks of antipsychotic exposure in a prospective, longitudinal, cohort of anti-psychotic-naïve individuals newly diagnosed with schizophrenia. Methods: Voxel-based morphometric (VBM) analysis was performed on magnetic resonance images (MRI) of the brain acquired before (t = 0) and after 3 weeks (t = 3 weeks) of antipsychotic treatment in 17 individuals with first-episode schizophrenia who had never received anti-psychotic treatment (7 males, 10 females). SPM (Statistical Parametric Mapping) 99 software using paired t test s was used to perform VBM analysis of greymatter volumetric differences between t = 0 and t = 3 weeks. Results:After 3 weeks of antipsychotic medication, significant clusters of volume excess in greymatter were detected in bilateral caudate, right parahippocampal gyrus and right postcentral gyrus. Clusters of volume deficits were detected in left superior frontal gyrus. Region-of-interest (ROI) confirmed caudate volumetric increased afterearly medication. Conclusions: Brain volumetric changes after 3 weeks medication suggests that drug-mediated neural and brain plasticity may occur during clinical recovery.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_HK
dc.titleEarly evidence of cerebral grey matter volume changed after treatment in neuroleptic naïve, newly diagnosed schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailDeng, Y: michdeng@hkusua.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.doi10.1016/j.schres.2007.12.080-
dc.identifier.hkuros152505-
dc.identifier.hkuros142842-
dc.identifier.volume98en_HK
dc.identifier.issuesuppl.-
dc.identifier.spage38en_HK
dc.identifier.epage38-

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