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Conference Paper: Neurocognitive and clinical predictors for vocational outcome following first episode schizophrenia: a 3 year prospective study

TitleNeurocognitive and clinical predictors for vocational outcome following first episode schizophrenia: a 3 year prospective study
Authors
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
The 20th International Congress on Schizophrenia Research, Savannah, GA., 2-6 April 2005. In Schizophrenia Bulletin, 2005, v. 31 n. 2, p. 320 How to Cite?
AbstractOBJECTIVE: We aim to identify early clinical and cognitive features that may predict vocational outcomes after first episode schizophrenia in Hong Kong. In addition, we investigated associated effects of unemployment on the symptomatic outcome of the illness at three years. METHOD: We studied the employment history of 93 patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders who was longitudinally followed up over three years. Pre-morbid factors, as well as clinical and cognitive variables which are present at the first episode were studied in relation to subsequent vocational outcomes. The relationship between employment status and clinical outcome at three years was also explored. RESULTS: The median number of months of full time employment is 8 out of 36 months. Forty-one percent of the patients did not return to full-time employment at all. Patient with poor vocational outcome (less than 8 months of full time employment) had more impaired scores on the premorbid adjustment scale (t = 2.889, p = .005) as well as more impaired work functioning at the time of presentation (t = 3.671, p < 0.001). They also performed worse in Logical memory (t = -2.072, p = .04), visual reproduction (t = -2.624, p = .01), as well as in both perseverative errors (t = 2.685, p = .009)and cateogory completion in the Wisconsin Card Sorting Test (t = -2.655, p = .009). A binary logistic regression model suggest that poor vocational outcome is predicted by poor pre-morbid occupational functioning, Premorbid adjustment, and executive function impairment after the first episode. Compared with others, patient with poor vocational outcome showed a decline in negative symptoms over the three year period. CONCLUSION: Vocational outcome is unfavorable after first-episode psychosis. Early predictors for poor outcome may identify at-risk patients for timely intervention. Unemployment is associated with an increase in negative symptoms.
DescriptionThis journal issue entitled: Special Issue: Abstracts of the XX International Congress on Schizophrenia Research
Persistent Identifierhttp://hdl.handle.net/10722/105504
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTam, DKen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorMIao, MYen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorTang, OWNen_HK
dc.date.accessioned2010-09-25T22:36:52Z-
dc.date.available2010-09-25T22:36:52Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 20th International Congress on Schizophrenia Research, Savannah, GA., 2-6 April 2005. In Schizophrenia Bulletin, 2005, v. 31 n. 2, p. 320en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105504-
dc.descriptionThis journal issue entitled: Special Issue: Abstracts of the XX International Congress on Schizophrenia Research-
dc.description.abstractOBJECTIVE: We aim to identify early clinical and cognitive features that may predict vocational outcomes after first episode schizophrenia in Hong Kong. In addition, we investigated associated effects of unemployment on the symptomatic outcome of the illness at three years. METHOD: We studied the employment history of 93 patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders who was longitudinally followed up over three years. Pre-morbid factors, as well as clinical and cognitive variables which are present at the first episode were studied in relation to subsequent vocational outcomes. The relationship between employment status and clinical outcome at three years was also explored. RESULTS: The median number of months of full time employment is 8 out of 36 months. Forty-one percent of the patients did not return to full-time employment at all. Patient with poor vocational outcome (less than 8 months of full time employment) had more impaired scores on the premorbid adjustment scale (t = 2.889, p = .005) as well as more impaired work functioning at the time of presentation (t = 3.671, p < 0.001). They also performed worse in Logical memory (t = -2.072, p = .04), visual reproduction (t = -2.624, p = .01), as well as in both perseverative errors (t = 2.685, p = .009)and cateogory completion in the Wisconsin Card Sorting Test (t = -2.655, p = .009). A binary logistic regression model suggest that poor vocational outcome is predicted by poor pre-morbid occupational functioning, Premorbid adjustment, and executive function impairment after the first episode. Compared with others, patient with poor vocational outcome showed a decline in negative symptoms over the three year period. CONCLUSION: Vocational outcome is unfavorable after first-episode psychosis. Early predictors for poor outcome may identify at-risk patients for timely intervention. Unemployment is associated with an increase in negative symptoms.-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.rightsSchizophrenia Bulletin. Copyright © Oxford University Press.en_HK
dc.titleNeurocognitive and clinical predictors for vocational outcome following first episode schizophrenia: a 3 year prospective studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0586-7614&volume=31&spage=320&epage=&date=2005&atitle=Neurocognitive+and+clinical+predictors+for+vocational+outcome+following+first+episode+schizophrenia:+a+3+year+prospective+studyen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailDunn, ELW: dunnlw@ha.org.hken_HK
dc.identifier.emailChan, WF: chanwf@ha.org.hken_HK
dc.identifier.emailTang, OWN: wntang@ha.org.hken_HK
dc.identifier.doi10.1093/schbul/sbi024-
dc.identifier.hkuros103299en_HK
dc.identifier.volume31en_HK
dc.identifier.issue2-
dc.identifier.spage320en_HK
dc.identifier.epage320-

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