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Conference Paper: High seroprevalence of borna disease virus infection in Chinese schizophrenic patients in Hong Kong

TitleHigh seroprevalence of borna disease virus infection in Chinese schizophrenic patients in Hong Kong
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2001, v. 49 n. 2 suppl., p. 28 How to Cite?
AbstractBorna Disease Virus (BDV) has been implicated in the aetiology of schizophrenia. We conducted the first seroepidemiological study in Hong Kong to investigate the relation of BDV infection and schizophrenia. Eighty-six Hong Kong Chinese patients with schizophrenia were recruited from a local psychiatric center. Two hundred and fifty-two healthy participants were recruited from the general public as controls. We found higher BDV seroprevalence of patients than controls by using both Western blot assay (10.5% vs 1.2%, OR = 9.7, 95% CI = 2.3±46.5, p < 0.001) and immunofluorescence assay (7.0% vs 1.2%, OR = 6.2, 95% CI = 1.4±32.2, p =. 0.01). The Western blot assay performed using purified virus detected antibodies against one or more BDV proteins p16, p40, p56 and p84. This finding provides some evidence for high seroprevalence of IgG anti-BDV in schizophrenic patients. The seroprevalence of both patients and healthy persons in Hong Kong are comparable with those reported from other countries. Hong Kong is a city with dense population and close contact with animals is very rare for the residence. Our findings suggest that animal contact may not be necessary for BDV transmission. Further studies concerning the pathophysiological mechanism of BDV in causing schizophrenia is important.
DescriptionThis journal suppl. contain Abstracts of the ICOSR
Persistent Identifierhttp://hdl.handle.net/10722/105496
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorGalabru, Jen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLin, CKen_HK
dc.contributor.authorSaron, Men_HK
dc.date.accessioned2010-09-25T22:36:32Z-
dc.date.available2010-09-25T22:36:32Z-
dc.date.issued2001en_HK
dc.identifier.citationSchizophrenia Research, 2001, v. 49 n. 2 suppl., p. 28en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105496-
dc.descriptionThis journal suppl. contain Abstracts of the ICOSR-
dc.description.abstractBorna Disease Virus (BDV) has been implicated in the aetiology of schizophrenia. We conducted the first seroepidemiological study in Hong Kong to investigate the relation of BDV infection and schizophrenia. Eighty-six Hong Kong Chinese patients with schizophrenia were recruited from a local psychiatric center. Two hundred and fifty-two healthy participants were recruited from the general public as controls. We found higher BDV seroprevalence of patients than controls by using both Western blot assay (10.5% vs 1.2%, OR = 9.7, 95% CI = 2.3±46.5, p < 0.001) and immunofluorescence assay (7.0% vs 1.2%, OR = 6.2, 95% CI = 1.4±32.2, p =. 0.01). The Western blot assay performed using purified virus detected antibodies against one or more BDV proteins p16, p40, p56 and p84. This finding provides some evidence for high seroprevalence of IgG anti-BDV in schizophrenic patients. The seroprevalence of both patients and healthy persons in Hong Kong are comparable with those reported from other countries. Hong Kong is a city with dense population and close contact with animals is very rare for the residence. Our findings suggest that animal contact may not be necessary for BDV transmission. Further studies concerning the pathophysiological mechanism of BDV in causing schizophrenia is important.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleHigh seroprevalence of borna disease virus infection in Chinese schizophrenic patients in Hong Kongen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=49 &issue=Supplement&spage=28&epage=&date=2001&atitle=High+seroprevalence+of+borna+disease+virus+infection+in+Chinese+schizophrenic+patients+in+Hong+Kongen_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailCheung, EFC: cheungfc@ha.org.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.doi10.1016/S0920-9964(01)00159-1-
dc.identifier.hkuros61771en_HK
dc.identifier.volume49en_HK
dc.identifier.issue2 suppl.en_HK
dc.identifier.spage28en_HK

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