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Conference Paper: Frontal and temporal lobe sources from mismatch negativity (MMN) in schizophrenia: an ERP and MR anatomical imaging study

TitleFrontal and temporal lobe sources from mismatch negativity (MMN) in schizophrenia: an ERP and MR anatomical imaging study
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 22 How to Cite?
AbstractBACKGROUND: MMN is an electrophysiological measure of automatic auditory change detection. A smaller MMN in patients with schizophrenia1,2 may reflect altered frontal activity3. METHODS: Following our report on the coordinates for frontal and temporal lobe dipole-loci contributing to normal MMN4, we replicated this result using brain electrical source analysis (BESA) and MR-images of the brain in 14 healthy subjects (34.8 years) and compared it with 17 patients (32 years) 15 years after the onset of schizophrenia. RESULTS: For MMN associated with a frequency deviant tone, asymmetric loci in the superior-temporal and left anterior-cingulate gyri were replicated, while that in the right inferior-frontal gyrus moved to the mid-frontal border (residual variance [RV] < 1%). Patients showed a modest MMN reduction, a weaker left temporal lobe source but essentially similar loci (RVf1%). Discrete changes in the locus of left temporal and cingulate sources were illustrated by plotting volumes around the group solution for individual’s data to 2% RV, with the radius illustrating the standard deviation of the distance to the better solutions for other subjects’ loci (also using a 2% RV criterion). The left temporal lobe source was marginally more medial in patients (5 mm, p < 0.01), while the left cingulate was more rostral (10 mm, p < 0.0001). CONCLUSION: The data show a degree of compensation of function despite altered source locations in the left hemisphere.
Persistent Identifierhttp://hdl.handle.net/10722/105460
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorOknina, Len_HK
dc.contributor.authorJuran, Sen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorPfueller, Uen_HK
dc.contributor.authorWeissbrod, Men_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2010-09-25T22:35:03Z-
dc.date.available2010-09-25T22:35:03Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 22en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105460-
dc.description.abstractBACKGROUND: MMN is an electrophysiological measure of automatic auditory change detection. A smaller MMN in patients with schizophrenia1,2 may reflect altered frontal activity3. METHODS: Following our report on the coordinates for frontal and temporal lobe dipole-loci contributing to normal MMN4, we replicated this result using brain electrical source analysis (BESA) and MR-images of the brain in 14 healthy subjects (34.8 years) and compared it with 17 patients (32 years) 15 years after the onset of schizophrenia. RESULTS: For MMN associated with a frequency deviant tone, asymmetric loci in the superior-temporal and left anterior-cingulate gyri were replicated, while that in the right inferior-frontal gyrus moved to the mid-frontal border (residual variance [RV] < 1%). Patients showed a modest MMN reduction, a weaker left temporal lobe source but essentially similar loci (RVf1%). Discrete changes in the locus of left temporal and cingulate sources were illustrated by plotting volumes around the group solution for individual’s data to 2% RV, with the radius illustrating the standard deviation of the distance to the better solutions for other subjects’ loci (also using a 2% RV criterion). The left temporal lobe source was marginally more medial in patients (5 mm, p < 0.01), while the left cingulate was more rostral (10 mm, p < 0.0001). CONCLUSION: The data show a degree of compensation of function despite altered source locations in the left hemisphere.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleFrontal and temporal lobe sources from mismatch negativity (MMN) in schizophrenia: an ERP and MR anatomical imaging studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67/1S&spage=22&epage=&date=2004&atitle=Frontal+and+temporal+lobe+sources+from+mismatch+negativity+(MMN)+in+schizophrenia:+an+ERP+and+MR+anatomical+imaging+studyen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.doi10.1016/j.schres.2003.10.001-
dc.identifier.hkuros88265en_HK
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.-
dc.identifier.spage22en_HK
dc.identifier.epage22-

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