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Conference Paper: Longitudinal profiles of neurocognitive function in first-episode pyschosis

TitleLongitudinal profiles of neurocognitive function in first-episode pyschosis
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 121, abstract A251 How to Cite?
AbstractNeurocognitive impairments in schizophrenia have been reported in numbers of studies. While some studies suggest global impairments in these patients, others demonstrated specific impairments. Implications of many previous studies were limited by methodological issues, such as recruitment of chronic cases and cross-sectional designs. In order to further investigate the cognitive profile in psychotic disorders, this study adopted a prospective design with an original sample of 153 patients with first-episode psychosis (FEP), out of which 90 were available for analysis up to 20-month follow-up. A set of neurocognitive tests, including attention (Continuous Performance Test), memory (Logical Memory, Visual Reproduction, Digit Forward Span), as well as executive function (Verbal Fluency, Wisconsin Card Sorting Test)., were carried out upon admission, discharge, and every 4 months up to 20 months. Results showed that patients as a group showed impairment in various domains but improvement over time was evident. In particular, two patterns of longitudinal performance were exhibited: (1) Performance on neurocognitive tests involving semantic components (logical memory and verbal fluency) tended to remain within a mild impairment range; (2) Performance on tests in which semantic components were not involved tended to improve over time and then level off within normal range. This suggests that neurocognitive functions in patients with FEP are generally impaired during the first episode. Most of these impairments improve with time, but those in which semantic components are involved are less likely to revert to normal level.
DescriptionThis journal suppl. entitled: XIth Biennial Winter Workshop on Schizophrenia
Session - 13. Cognition
Persistent Identifierhttp://hdl.handle.net/10722/105458
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorTso, Fen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorMiao, YKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorTang, OWNen_HK
dc.date.accessioned2010-09-25T22:34:58Z-
dc.date.available2010-09-25T22:34:58Z-
dc.date.issued2002en_HK
dc.identifier.citationThe 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 121, abstract A251en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105458-
dc.descriptionThis journal suppl. entitled: XIth Biennial Winter Workshop on Schizophrenia-
dc.descriptionSession - 13. Cognition-
dc.description.abstractNeurocognitive impairments in schizophrenia have been reported in numbers of studies. While some studies suggest global impairments in these patients, others demonstrated specific impairments. Implications of many previous studies were limited by methodological issues, such as recruitment of chronic cases and cross-sectional designs. In order to further investigate the cognitive profile in psychotic disorders, this study adopted a prospective design with an original sample of 153 patients with first-episode psychosis (FEP), out of which 90 were available for analysis up to 20-month follow-up. A set of neurocognitive tests, including attention (Continuous Performance Test), memory (Logical Memory, Visual Reproduction, Digit Forward Span), as well as executive function (Verbal Fluency, Wisconsin Card Sorting Test)., were carried out upon admission, discharge, and every 4 months up to 20 months. Results showed that patients as a group showed impairment in various domains but improvement over time was evident. In particular, two patterns of longitudinal performance were exhibited: (1) Performance on neurocognitive tests involving semantic components (logical memory and verbal fluency) tended to remain within a mild impairment range; (2) Performance on tests in which semantic components were not involved tended to improve over time and then level off within normal range. This suggests that neurocognitive functions in patients with FEP are generally impaired during the first episode. Most of these impairments improve with time, but those in which semantic components are involved are less likely to revert to normal level.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleLongitudinal profiles of neurocognitive function in first-episode pyschosisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=53&issue=3&spage=121&epage=&date=2002&atitle=Longitudinal+profiles+of+neurocognitive+function+in+first-episode+pyschosisen_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailDunn, ELW: dunnlw@ha.org.hken_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailChan, WF: chanwf@ha.org.hken_HK
dc.identifier.emailTang, OWN: wntang@ha.org.hken_HK
dc.identifier.doi10.1016/S0920-9964(01)00381-4-
dc.identifier.hkuros73392en_HK
dc.identifier.volume53en_HK
dc.identifier.issue3 suppl. 1-
dc.identifier.spage121, abstract A251en_HK
dc.identifier.epage121, abstract A251-

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