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Conference Paper: A comprehensive computational morphometric analysis of the brain in neuroleptic-naive schizophrenia

TitleA comprehensive computational morphometric analysis of the brain in neuroleptic-naive schizophrenia
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. In Schizophrenia Research, 2006, v. 81, p. 165-166, abstract no. 329 How to Cite?
AbstractBACKGROUND: Neuroleptic treatment confounds the interpretation of studies of brain morphology in schizophrenia. We hypothesized that fronto-temporal and subcortico-limbic abnormalities, particularly the caudate nuclei, would be independent of neuroleptic treatment in first episode schizophrenia. METHODS: We performed a comprehensive computational morphometry analysis of the brain in 29 never-medicated individuals with first-episode schizophrenia and 40 healthy controls. Groups were balanced for age, sex, handedness, ethnicity, paternal socioeconomic status, and height. Patients were a consecutive series presenting to their local hospital for treatment for the first time. Healthy controls were recruited from the local community by advertisement. Voxel-based analysis of grey matter, white matter and CSF volumes was performed. RESULTS: Grey matter, white matter and CSF: global brain volume ratios were significantly smaller in patients. Patients had significantly less grey matter volume in bilateral caudate nuclei, right thalamus, right prefrontal cortex, bilateral cingulate gyrus, bilateral parahippocampal gyri, right superior temporal gyrus and bilateral cerebellum. They also had significantly less white matter volume in the right anterior limb of the internal capsule, right fronto-occipital fasciculus and bilateral fornices, and significantly greater CSF volume especially in the right lateral ventricle. CONCLUSIONS: Our data indeed suggest that fronto-temporal and subcortical-limbic circuits are morphologically abnormal in schizophrenia. Thus, unrelated to pharmacotherapy, periventricular changes, particularly smaller caudate volumes that are evident in neuroleptic naı¨ve patients, are likely to predate clinical expression of psychosis.
DescriptionPoster Presentation
Persistent Identifierhttp://hdl.handle.net/10722/105442
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorCheung, JPYen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTsang, JTKen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorBullmore, Een_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-25T22:34:19Z-
dc.date.available2010-09-25T22:34:19Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. In Schizophrenia Research, 2006, v. 81, p. 165-166, abstract no. 329en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105442-
dc.descriptionPoster Presentation-
dc.description.abstractBACKGROUND: Neuroleptic treatment confounds the interpretation of studies of brain morphology in schizophrenia. We hypothesized that fronto-temporal and subcortico-limbic abnormalities, particularly the caudate nuclei, would be independent of neuroleptic treatment in first episode schizophrenia. METHODS: We performed a comprehensive computational morphometry analysis of the brain in 29 never-medicated individuals with first-episode schizophrenia and 40 healthy controls. Groups were balanced for age, sex, handedness, ethnicity, paternal socioeconomic status, and height. Patients were a consecutive series presenting to their local hospital for treatment for the first time. Healthy controls were recruited from the local community by advertisement. Voxel-based analysis of grey matter, white matter and CSF volumes was performed. RESULTS: Grey matter, white matter and CSF: global brain volume ratios were significantly smaller in patients. Patients had significantly less grey matter volume in bilateral caudate nuclei, right thalamus, right prefrontal cortex, bilateral cingulate gyrus, bilateral parahippocampal gyri, right superior temporal gyrus and bilateral cerebellum. They also had significantly less white matter volume in the right anterior limb of the internal capsule, right fronto-occipital fasciculus and bilateral fornices, and significantly greater CSF volume especially in the right lateral ventricle. CONCLUSIONS: Our data indeed suggest that fronto-temporal and subcortical-limbic circuits are morphologically abnormal in schizophrenia. Thus, unrelated to pharmacotherapy, periventricular changes, particularly smaller caudate volumes that are evident in neuroleptic naı¨ve patients, are likely to predate clinical expression of psychosis.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleA comprehensive computational morphometric analysis of the brain in neuroleptic-naive schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=81&spage=165&epage=&date=2006&atitle=A+comprehensive+computational+morphometric+analysis+of+the+brain+in+neuroleptic-naive+schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.doi10.1016/j.schres.2006.01.006-
dc.identifier.hkuros116299en_HK
dc.identifier.hkuros143663-
dc.identifier.volume81en_HK
dc.identifier.spage165, abstract no. 329en_HK
dc.identifier.epage166-

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