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Conference Paper: Sensitivity and Specificity of neurological signs using the Cambridge Neurological Invertory in Chinese patients with schizophrenia

TitleSensitivity and Specificity of neurological signs using the Cambridge Neurological Invertory in Chinese patients with schizophrenia
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 137, abstract no. 260 How to Cite?
AbstractOBJECTIVE: This study attempted to examine the sensitivity and specificity of neurological signs in Chinese patients with schizophrenia. METHODS: A total of 250 schizophrenic patients and 90 normal controls were recruited. The Cambridge Neurological Inventory (CNI) was used to assess the prevalence of neurological signs. The CNI consists of seven subscales. Three soft signs subscales (motor coordination, sensory integration, disinhibition) and four hard signs subscales (extrapyramidal signs, dyskinesia, catatonia, pyramidal signs). RESULTS: The findings showed that patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs ( p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs ( p < 0.0005). In view of sensitivity and specificity, the three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the remaining hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0.63 and specificity of 0.71; whereas a cut-off of 1 in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A cut-off of 5 in total neurological signs also gets a sensitivity of 0.81 and specificity of 0.73. High levels of neurological abnormality characterize schizophrenic patients. CONCLUSION: An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more differentially associated with schizophrenia than are hard signs in the Chinese sample.
Persistent Identifierhttp://hdl.handle.net/10722/105437
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorChan, RCKen_HK
dc.date.accessioned2010-09-25T22:34:07Z-
dc.date.available2010-09-25T22:34:07Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 137, abstract no. 260en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105437-
dc.description.abstractOBJECTIVE: This study attempted to examine the sensitivity and specificity of neurological signs in Chinese patients with schizophrenia. METHODS: A total of 250 schizophrenic patients and 90 normal controls were recruited. The Cambridge Neurological Inventory (CNI) was used to assess the prevalence of neurological signs. The CNI consists of seven subscales. Three soft signs subscales (motor coordination, sensory integration, disinhibition) and four hard signs subscales (extrapyramidal signs, dyskinesia, catatonia, pyramidal signs). RESULTS: The findings showed that patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs ( p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs ( p < 0.0005). In view of sensitivity and specificity, the three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the remaining hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0.63 and specificity of 0.71; whereas a cut-off of 1 in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A cut-off of 5 in total neurological signs also gets a sensitivity of 0.81 and specificity of 0.73. High levels of neurological abnormality characterize schizophrenic patients. CONCLUSION: An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more differentially associated with schizophrenia than are hard signs in the Chinese sample.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleSensitivity and Specificity of neurological signs using the Cambridge Neurological Invertory in Chinese patients with schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67/1S&spage=137&epage=&date=2004&atitle=Sensitivity+and+Specificity+of+neurological+signs+using+the+Cambridge+Neurological+Invertory+in+Chinese+patients+with+schizophreniaen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.doi10.1016/j.schres.2003.10.001-
dc.identifier.hkuros88263en_HK
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.-
dc.identifier.spage137, abstract no. 260en_HK
dc.identifier.epage137, abstract no. 260-

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