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Conference Paper: Early cerebral grey matter excess in basal ganglia after early treatment in first-onset, never-medicated schizophrenia

TitleEarly cerebral grey matter excess in basal ganglia after early treatment in first-onset, never-medicated schizophrenia
Authors
Issue Date2007
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15622975.asp
Citation
The 2nd International Congress of Biological Psychiatry, Santiago, Chile, 17-21 April 2007. In The World Journal of Biological Psychiatry, 2007, v. 8 n. S1, p. 171, abstract no. P-08-02 How to Cite?
AbstractIntroduction: In the early weeks following neuroleptic treatment, patients never previously been exposed to antipsychotic medication and presenting with first-episode of schizophrenia may already demonstrate brain volumetric differences. Method: We used a comprehensive computational morphometry analysis of the brain. 38 individuals with first-episode psychosis were balanced for age, sex, handedness, ethnicity, height, education in years, paternal socio-economic status and PANSS score. They were a consecutive series presenting to their local hospital for treatment. BAMM (Brain activation and morphological mapping) software was used to measure grey matter, white matter and CSF volumes. 12 were treated with neuroleptics (NT) and 26 were neuroleptic-naìve (NN). The NT group had been scanned in the earlier stage of the project as a pilot group and did not differ in MRI scanning parameters. Groups did not differ in age, sex, socioeconomic class, handedness, ethnicity. In the NT group, significant clusters of volume excess in grey matter was detected bilaterally in the caudate, putamen, cingulate, cerebellum, and brainstem after around 18 days of neuroleptic treatment. Region-of-interest measurement of the caudate using T1 scans, 1.2mm, contiguous, 128 slices was done by a single operator blind to group membership. Results: It showed caudate volume significantly larger by 16% (on the left, p 0.012, 2 tailed) and 13% (on the right, p 0.028, 2 tailed) in the NT group. Conclusion: This is the first study to demonstrate that basal ganglia and extrastriatal grey matter excess is likely to occur early on within three weeks of initiating neuroleptic treatment.
Persistent Identifierhttp://hdl.handle.net/10722/105414
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 1.938

 

DC FieldValueLanguage
dc.contributor.authorDeng, Yen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTsang, JTKen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorBullmore, Een_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SE-
dc.date.accessioned2010-09-25T22:33:10Z-
dc.date.available2010-09-25T22:33:10Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2nd International Congress of Biological Psychiatry, Santiago, Chile, 17-21 April 2007. In The World Journal of Biological Psychiatry, 2007, v. 8 n. S1, p. 171, abstract no. P-08-02-
dc.identifier.issn1562-2975-
dc.identifier.urihttp://hdl.handle.net/10722/105414-
dc.description.abstractIntroduction: In the early weeks following neuroleptic treatment, patients never previously been exposed to antipsychotic medication and presenting with first-episode of schizophrenia may already demonstrate brain volumetric differences. Method: We used a comprehensive computational morphometry analysis of the brain. 38 individuals with first-episode psychosis were balanced for age, sex, handedness, ethnicity, height, education in years, paternal socio-economic status and PANSS score. They were a consecutive series presenting to their local hospital for treatment. BAMM (Brain activation and morphological mapping) software was used to measure grey matter, white matter and CSF volumes. 12 were treated with neuroleptics (NT) and 26 were neuroleptic-naìve (NN). The NT group had been scanned in the earlier stage of the project as a pilot group and did not differ in MRI scanning parameters. Groups did not differ in age, sex, socioeconomic class, handedness, ethnicity. In the NT group, significant clusters of volume excess in grey matter was detected bilaterally in the caudate, putamen, cingulate, cerebellum, and brainstem after around 18 days of neuroleptic treatment. Region-of-interest measurement of the caudate using T1 scans, 1.2mm, contiguous, 128 slices was done by a single operator blind to group membership. Results: It showed caudate volume significantly larger by 16% (on the left, p 0.012, 2 tailed) and 13% (on the right, p 0.028, 2 tailed) in the NT group. Conclusion: This is the first study to demonstrate that basal ganglia and extrastriatal grey matter excess is likely to occur early on within three weeks of initiating neuroleptic treatment.-
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15622975.asp-
dc.relation.ispartofThe World Journal of Biological Psychiatryen_HK
dc.rightsThe World Journal of Biological Psychiatry. Copyright © Informa Healthcare.-
dc.titleEarly cerebral grey matter excess in basal ganglia after early treatment in first-onset, never-medicated schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.hkuros133311en_HK
dc.identifier.volume8-
dc.identifier.issueS1-
dc.identifier.spage171, abstract no. P-08-02-
dc.identifier.epage171, abstract no. P-08-02-

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