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Conference Paper: Impaired temporal inhibition of irrelevant processing in patients with schizophrenia: evidence from attentional blink, visual backward masking, and attentional modulation of prepulse inhibition

TitleImpaired temporal inhibition of irrelevant processing in patients with schizophrenia: evidence from attentional blink, visual backward masking, and attentional modulation of prepulse inhibition
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 269, abstract no. 570 How to Cite?
AbstractMETHODS: The expression of attentional blink (AB) in schizophrenic patients (n = 23) was compared to healthy subjects (n = 24) in a dual-target rapid serial visual presentation (RSVP) paradigm in which a sequence of discrete stimuli was presented in rapid succession. Target identification accuracy was then correlated with performances in a visual backward masking (VBM) task and measures of prepulse inhibition (PPI). In the VBM task, subjects were required to name a letter which was masked at SOAs 16– 83 ms. Prepulse inhibition (PPI) of acoustic startle response was measured for prepulse – pulse intervals of 60 and 120 ms. To investigate the attentional modulation of PPI, subjects were instructed to count either high- or low-tone prepulse and ignore the other prepulse. RESULTS: Schizophrenic patients showed significant enhancement of AB, greater susceptibility to VBM, and lack of PPI when compared to healthy subjects. The latter two findings may reflect a reduced ability to inhibit transient processing of disruptive stimuli in the patients. Greater AB magnitude in patients was correlated with greater susceptibility to VBM; lower second-target accuracy in the AB task was correlated with weaker PPI in the ignored prepulse (120 ms) condition. In the controls, AB magnitude correlated negatively with VBM susceptibility; first-target accuracy in the AB task correlated negatively with the PPI in the attended prepulse (60 ms) condition. CONCLUSION: This pattern of results suggests that enhancement of the AB effect in patients with Schizophrenia may be due to a deficit in the inhibition of irrelevant information processing.
Persistent Identifierhttp://hdl.handle.net/10722/105411
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorYee, BKen_HK
dc.date.accessioned2010-09-25T22:33:02Z-
dc.date.available2010-09-25T22:33:02Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, 2004, v. 67 n. 1 suppl., p. 269, abstract no. 570en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105411-
dc.description.abstractMETHODS: The expression of attentional blink (AB) in schizophrenic patients (n = 23) was compared to healthy subjects (n = 24) in a dual-target rapid serial visual presentation (RSVP) paradigm in which a sequence of discrete stimuli was presented in rapid succession. Target identification accuracy was then correlated with performances in a visual backward masking (VBM) task and measures of prepulse inhibition (PPI). In the VBM task, subjects were required to name a letter which was masked at SOAs 16– 83 ms. Prepulse inhibition (PPI) of acoustic startle response was measured for prepulse – pulse intervals of 60 and 120 ms. To investigate the attentional modulation of PPI, subjects were instructed to count either high- or low-tone prepulse and ignore the other prepulse. RESULTS: Schizophrenic patients showed significant enhancement of AB, greater susceptibility to VBM, and lack of PPI when compared to healthy subjects. The latter two findings may reflect a reduced ability to inhibit transient processing of disruptive stimuli in the patients. Greater AB magnitude in patients was correlated with greater susceptibility to VBM; lower second-target accuracy in the AB task was correlated with weaker PPI in the ignored prepulse (120 ms) condition. In the controls, AB magnitude correlated negatively with VBM susceptibility; first-target accuracy in the AB task correlated negatively with the PPI in the attended prepulse (60 ms) condition. CONCLUSION: This pattern of results suggests that enhancement of the AB effect in patients with Schizophrenia may be due to a deficit in the inhibition of irrelevant information processing.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleImpaired temporal inhibition of irrelevant processing in patients with schizophrenia: evidence from attentional blink, visual backward masking, and attentional modulation of prepulse inhibitionen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67&issue=1&spage=269&epage=&date=2004&atitle=Impaired+temporal+inhibition+of+irrelevant+processing+in+patients+with+schizophrenia:+evidence+from+attentional+blink,+visual+backward+masking,+and+attentional+modulation+of+prepulse+inhibitionen_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.doi10.1016/j.schres.2003.10.001-
dc.identifier.hkuros88038en_HK
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.en_HK
dc.identifier.spage269, abstract no. 570en_HK
dc.identifier.epage269, abstract no. 570-

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