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Conference Paper: Cognitive predictors of clinical outcome in early course of psychosis

TitleCognitive predictors of clinical outcome in early course of psychosis
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 121, abstract A252 How to Cite?
Persistent Identifierhttp://hdl.handle.net/10722/105396
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorTso, Fen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorDunn, ELWen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChan, WFen_HK
dc.contributor.authorMiao, YKen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorWong, CKen_HK
dc.contributor.authorTang, OWNen_HK
dc.date.accessioned2010-09-25T22:32:25Z-
dc.date.available2010-09-25T22:32:25Z-
dc.date.issued2002en_HK
dc.identifier.citationThe 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 121, abstract A252en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105396-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleCognitive predictors of clinical outcome in early course of psychosisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=53&issue=3&spage=121&epage=&date=2002&atitle=Cognitive+predictors+of+clinical+outcome+in+early+course+of+psychosisen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.emailDunn, ELW: dunnlw@ha.org.hken_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailChan, WF: chanwf@ha.org.hken_HK
dc.identifier.emailTang, OWN: wntang@ha.org.hken_HK
dc.identifier.doi10.1016/S0920-9964(01)00381-4-
dc.identifier.hkuros73395en_HK
dc.identifier.volume53en_HK
dc.identifier.issue3 suppl. 1en_HK
dc.identifier.spage121, abstract A252en_HK
dc.identifier.epage121, abstract A252-
dc.deduplication.noteThis study aims to explore potential predictors of clinical outcomes in terms of cognitive markers in a psychosis. A total of 153 patients presenting first-episode psychosis were recruited, out of which 90 were available for analysis up to 20-month follow-up. They were tested with neurocognitive tests including Logical Memory Test, Visual Reproduction (VR). Verbal Fluency Test (VF), and Wisconsin Card Sorting Test (WCST) upon admission, discharge, and every 4 months up to 20-month follow-up. Clinical outcome was measured by the Positive and Negative Syndrome Scale (PANSS). Linear regression analysis, with independent variables of the test scores at admission and discharge (for the first-episode psychosis), as well as improvement between the two time points, was employed in identifying potential predictors of clinical outcomes. Dependent variables were positive symptom, negative symptom, and total symptom scores of PANSS at 20-month follow-up. Improvement in WCST category score was the only predictor of positive symptoms which accounted for 6% of variance [F(1,81 = 5.737, p = 0.019), while performance on VF at admission and VR (immediate recall) at discharge altogether accounted for 12% of variance of negative symptoms [F(2,80) = 6.334, p = 0.003]. For total PANSS score, improvement in WCST category score and performance on VR Ždelayed recall. Upon discharge accounted for 11% of variance [F(2,80) = 6.133, p = 0.003]. In conclusion, performance on WCST category score and VR appear to be crucial determinants of clinical outcome in early course of illness.-

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