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Conference Paper: Association Between Monoamine Oxidase A Gene (CA)n Polymorphism and Risk for Schizophrenia in the Chinese Population

TitleAssociation Between Monoamine Oxidase A Gene (CA)n Polymorphism and Risk for Schizophrenia in the Chinese Population
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc.
Citation
The 12th World Congress of Psychiatric Genetics (ISPG 2004), Dublin, Ireland, UK., 9-13 October 2004. In American Journal of Medical Genetics, 2004, v. 130B n. 1, p. 77, abstract P7.13 How to Cite?
AbstractMonoamine oxidase plays an important role in the central regulation of monoamine neurotransmitters which are implicated in the pathogenesis of schizophrenia, mood regulation and abnormal behaviours such as impulsivity, suicide and violence. We conducted a population based case-control study to investigate the association of the microsatellite CA-repeats in intron 2 of the MAOA gene, located on the X chromosome, with the susceptibility for schizophrenia and its associated neurocognitive and behavioural phenotypes in the Han Chinese population. Four-hundred-eighty-six unrelated schizophrenic patients with detailed clinical and neurocognitive assessment and 516 healthy subjects were recruited in Hong Kong. We found a significant association between MAOA allele 116 and male patients with schizophrenia (chisquare = 9.68, P = 0.002, odds ratio = 1.64, 95% confidence interval = 1.20–2.24). Further analysis of the clinical and neurocognitive variables in male patients showed a significant association between MAOA allele 116 and history of suicidal behaviour (chi-square = 11.49, P = 0.001, odds ratio = 2.27, 95% confidence interval = 1.41–3.65). Our findings suggest that either the MAOA microsatellite CA-repeats itself or a nearby genetic variant in linkage disequilibrium may influence the risk for schizophrenia and suicidal tendency in men. This may also imply a different genetic mechanism for male and female for expression of the schizophrenia phenotype. Further studies to examine the functional implication of the MAOA microsatellite CA-repeats and its nearby genetic variants in the gender specific pathogenesis of schizophrenia are necessary.
DescriptionThis journal issue entitled: Special Issue: Abstracts for the XIIth World Congress of Psychiatric Genetics
Persistent Identifierhttp://hdl.handle.net/10722/105383
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHui, TCKen_HK
dc.contributor.authorChau, TWYen_HK
dc.contributor.authorChan, RCKen_HK
dc.contributor.authorCollier, Den_HK
dc.date.accessioned2010-09-25T22:31:53Z-
dc.date.available2010-09-25T22:31:53Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th World Congress of Psychiatric Genetics (ISPG 2004), Dublin, Ireland, UK., 9-13 October 2004. In American Journal of Medical Genetics, 2004, v. 130B n. 1, p. 77, abstract P7.13en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105383-
dc.descriptionThis journal issue entitled: Special Issue: Abstracts for the XIIth World Congress of Psychiatric Genetics-
dc.description.abstractMonoamine oxidase plays an important role in the central regulation of monoamine neurotransmitters which are implicated in the pathogenesis of schizophrenia, mood regulation and abnormal behaviours such as impulsivity, suicide and violence. We conducted a population based case-control study to investigate the association of the microsatellite CA-repeats in intron 2 of the MAOA gene, located on the X chromosome, with the susceptibility for schizophrenia and its associated neurocognitive and behavioural phenotypes in the Han Chinese population. Four-hundred-eighty-six unrelated schizophrenic patients with detailed clinical and neurocognitive assessment and 516 healthy subjects were recruited in Hong Kong. We found a significant association between MAOA allele 116 and male patients with schizophrenia (chisquare = 9.68, P = 0.002, odds ratio = 1.64, 95% confidence interval = 1.20–2.24). Further analysis of the clinical and neurocognitive variables in male patients showed a significant association between MAOA allele 116 and history of suicidal behaviour (chi-square = 11.49, P = 0.001, odds ratio = 2.27, 95% confidence interval = 1.41–3.65). Our findings suggest that either the MAOA microsatellite CA-repeats itself or a nearby genetic variant in linkage disequilibrium may influence the risk for schizophrenia and suicidal tendency in men. This may also imply a different genetic mechanism for male and female for expression of the schizophrenia phenotype. Further studies to examine the functional implication of the MAOA microsatellite CA-repeats and its nearby genetic variants in the gender specific pathogenesis of schizophrenia are necessary.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.titleAssociation Between Monoamine Oxidase A Gene (CA)n Polymorphism and Risk for Schizophrenia in the Chinese Populationen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=130B&spage=77&epage=&date=2004&atitle=Association+Between+Monoamine+Oxidase+A+Gene+(CA)n+Polymorphism+and+Risk+for+Schizophrenia+in+the+Chinese+Populationen_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@HKUCC.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChan, RCK: ckrchan@graduate.hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.doi10.1002/ajmg.b.30101-
dc.identifier.hkuros95411en_HK
dc.identifier.volume130Ben_HK
dc.identifier.issue1-
dc.identifier.spage77, abstract P7.13en_HK
dc.identifier.epage77, abstract P7.13-

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