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Conference Paper: Limbic and striatal grey matter excess in first-onset schizophrenia

TitleLimbic and striatal grey matter excess in first-onset schizophrenia
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, v. 67 n. 1 suppl., p. 94-95, abstract no. 159 How to Cite?
AbstractOBJECTIVE: We performed voxel-based morphometric analysis of structural MRI scans of first-episode schizophrenic subjects to identify abnormality in the volume of brain regions. METHODS: Eighteen patients consecutively admitted to the Accident and Emergency Department with a first-episode diag-nosis of Schizophrenia were recruited. Twenty-eight normal healthy volunteers matched for age, sex, parental socioeconomic status, ethnicity, and handedness were recruited from the local community. Five patients were neuroleptic-naı¨ve, and the rest had received neuroleptic medication for an average of a week prior to scanning. The whole brain near axial dual-echo data set was analysed using BAMM software (Brain Analysis Morphological Mapping version 2.5, Cambridge University). This allowed fully automated brain segmentation into grey and white matter and significant volume differences between patient group and controls were mapped across the brain. RESULTS: Results indicated that the two groups did not differ in the whole brain volume, grey matter nor cerebrospinal fluid volume. However, significant unilateral grey matter excess in the patient group was noted in the cingulate gyrus, parahippocampal gyrus, caudate, putamen and globus pallidus. CONCLUSION: These results suggest that there is abnormality of the striato-limbic circuitry in early psychosis..
Persistent Identifierhttp://hdl.handle.net/10722/105381
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-25T22:31:48Z-
dc.date.available2010-09-25T22:31:48Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, v. 67 n. 1 suppl., p. 94-95, abstract no. 159en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105381-
dc.description.abstractOBJECTIVE: We performed voxel-based morphometric analysis of structural MRI scans of first-episode schizophrenic subjects to identify abnormality in the volume of brain regions. METHODS: Eighteen patients consecutively admitted to the Accident and Emergency Department with a first-episode diag-nosis of Schizophrenia were recruited. Twenty-eight normal healthy volunteers matched for age, sex, parental socioeconomic status, ethnicity, and handedness were recruited from the local community. Five patients were neuroleptic-naı¨ve, and the rest had received neuroleptic medication for an average of a week prior to scanning. The whole brain near axial dual-echo data set was analysed using BAMM software (Brain Analysis Morphological Mapping version 2.5, Cambridge University). This allowed fully automated brain segmentation into grey and white matter and significant volume differences between patient group and controls were mapped across the brain. RESULTS: Results indicated that the two groups did not differ in the whole brain volume, grey matter nor cerebrospinal fluid volume. However, significant unilateral grey matter excess in the patient group was noted in the cingulate gyrus, parahippocampal gyrus, caudate, putamen and globus pallidus. CONCLUSION: These results suggest that there is abnormality of the striato-limbic circuitry in early psychosis..-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleLimbic and striatal grey matter excess in first-onset schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67&issue=1&spage=94&epage=&date=2004&atitle=Limbic+and+striatal+grey+matter+excess+in+first-onset+schizophreniaen_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.email95-
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.doi10.1016/j.schres.2003.10.001-
dc.identifier.hkuros88036en_HK
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.en_HK
dc.identifier.spage94, abstract no. 159en_HK

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