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Conference Paper: No evidence of association between a polymorphism the COMT gene and clinical phenotypes of schizophrenia in China

TitleNo evidence of association between a polymorphism the COMT gene and clinical phenotypes of schizophrenia in China
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc.
Citation
The 8th World Congress on Psychiatric Genetics (WCPG 2000), Versailles, France, 27-31 August 20000. In American Journal of Medical Genetics, 2000, v. 96 n. 4, p. 527, abstract P204 How to Cite?
AbstractCatechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, has been implicated in the pathogenesis of schizophrenia. Genetic polymorphism with a valine to methionine substitution at amino acid 158 leading to low-activity variant of the enzyme has been found to be associated with schizophrenia and violent behavior. However, negative findings have also been reported. We conducted a case-control study of the val158met polymorphism of the COMT gene to investigate the possible association with schizophrenia and clinical phenotypes in Chinese. Two hundred and six unrelated schizophrenic patients and 286 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotype and allele frequencies of COMT polymorphisms by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes including frontal lobe function, clinical symptoms, treatment response, suicide and violent behavior. Our data suggest that val158met polymorphism of COMT gene is not associated with schizophrenia at least at the diagnostic level. In view of our modest sample size and the low frequency of homozygous met158 genotype in the Chinese population, further large scale studies with detailed characterization of endophenotypes are essential for mapping this gene to schizophrenia and the associated traits.
DescriptionThis journal issue entitled: Special Issue: Abstracts of Presentations: Eighth World Congress on Psychiatric Genetics, Versailles, France
Persistent Identifierhttp://hdl.handle.net/10722/105357
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100

 

DC FieldValueLanguage
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorShum, PCen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorHui, TCKen_HK
dc.contributor.authorKwok, CLen_HK
dc.contributor.authorMak-Lieh, Fen_HK
dc.contributor.authorZhao, JHen_HK
dc.contributor.authorCollier, Den_HK
dc.contributor.authorMurray, Ren_HK
dc.date.accessioned2010-09-25T22:30:48Z-
dc.date.available2010-09-25T22:30:48Z-
dc.date.issued2000en_HK
dc.identifier.citationThe 8th World Congress on Psychiatric Genetics (WCPG 2000), Versailles, France, 27-31 August 20000. In American Journal of Medical Genetics, 2000, v. 96 n. 4, p. 527, abstract P204en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105357-
dc.descriptionThis journal issue entitled: Special Issue: Abstracts of Presentations: Eighth World Congress on Psychiatric Genetics, Versailles, France-
dc.description.abstractCatechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, has been implicated in the pathogenesis of schizophrenia. Genetic polymorphism with a valine to methionine substitution at amino acid 158 leading to low-activity variant of the enzyme has been found to be associated with schizophrenia and violent behavior. However, negative findings have also been reported. We conducted a case-control study of the val158met polymorphism of the COMT gene to investigate the possible association with schizophrenia and clinical phenotypes in Chinese. Two hundred and six unrelated schizophrenic patients and 286 unrelated healthy controls of Han Chinese descent in Hong Kong were compared for genotype and allele frequencies of COMT polymorphisms by PCR amplification and restriction analysis. No evidence of association was detected at the diagnostic level and various clinical phenotypes including frontal lobe function, clinical symptoms, treatment response, suicide and violent behavior. Our data suggest that val158met polymorphism of COMT gene is not associated with schizophrenia at least at the diagnostic level. In view of our modest sample size and the low frequency of homozygous met158 genotype in the Chinese population, further large scale studies with detailed characterization of endophenotypes are essential for mapping this gene to schizophrenia and the associated traits.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofAmerican Journal of Medical Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.titleNo evidence of association between a polymorphism the COMT gene and clinical phenotypes of schizophrenia in Chinaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-7299&volume=96&issue=4&spage=527&epage=&date=2000&atitle=No+evidence+of+association+between+a+polymorphism+the+COMT+gene+and+clinical+phenotypes+of+schizophrenia+in+Chinaen_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailCheung, EFC: cheungfc@ha.org.hken_HK
dc.identifier.emailMak-Lieh, F: flmak@hku.hken_HK
dc.identifier.hkuros61881en_HK
dc.identifier.volume96en_HK
dc.identifier.issue4en_HK
dc.identifier.spage527, abstract P204en_HK
dc.identifier.epage527, abstract P204-

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