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Conference Paper: Borna disease virus and Schizophrenia - a study of seroprevalence and clinical variables

TitleBorna disease virus and Schizophrenia - a study of seroprevalence and clinical variables
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 84, abstract A148 How to Cite?
AbstractViral causes have been implicated as one of the environmental aetiological factors of schizophrenia. Borna disease virus (BDV) is a negative-stranded, enveloped, noncytolytic RNA virus characterized by neurotropism and a wide host range. The clinical, neuroanatomical and neurochemical changes observed in experimentally infected animals suggests that BDV may be related to human psychiatric disorders including schizophrenia. Evidence of human BDV infection has also emerged recently. We examined the prevalence of BDV-specific antibodies in 432 Hong Kong Chinese patients with schizophrenia using Western blot technique as well as the relationship between seropositivity and clinical variables by comparing seropositve and seronegative patients. The serum samples of 480 healthy Hong Kong Chinese blood donors matched for age were used as controls. We found a significantly higher BDV seroprevalence rate in patients with schizophrenia Ž22.7%. than healthy blood donors Ž11.5%.. The odds ratio for BDV seropositivity was 2.27 Ž95% confidence intervals1.02–2.28.. No association between seropositivity and patient status, age, age of onset, duration of illness, duration of untreated psychosis, treatment response, subtype of illness, dosages of antipsychotic medication, the presence of family history of psychiatric disorder and scores on the PANSS was found. Our results suggest that BDV may be important in the pathogenesis of schizophrenia in Hong Kong and the significantly higher seropositivity rate amongpatients with schizophrenia is consistent with previous studies. Further research is indicated to clearly elucidate the characteristics of patients for whom BDV may be aetiologically relevant.
DescriptionThis journal suppl. entitled: XIth Biennial Winter Workshop on Schizophrenia
Persistent Identifierhttp://hdl.handle.net/10722/105351
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorGalabru, Jen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorLin, CKen_HK
dc.contributor.authorSaron, MFen_HK
dc.date.accessioned2010-09-25T22:30:33Z-
dc.date.available2010-09-25T22:30:33Z-
dc.date.issued2002en_HK
dc.identifier.citationThe 11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 24 February-1 March 2002. In Schizophrenia Research, 2002, v. 53 n. 3 suppl. 1, p. 84, abstract A148en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105351-
dc.descriptionThis journal suppl. entitled: XIth Biennial Winter Workshop on Schizophrenia-
dc.description.abstractViral causes have been implicated as one of the environmental aetiological factors of schizophrenia. Borna disease virus (BDV) is a negative-stranded, enveloped, noncytolytic RNA virus characterized by neurotropism and a wide host range. The clinical, neuroanatomical and neurochemical changes observed in experimentally infected animals suggests that BDV may be related to human psychiatric disorders including schizophrenia. Evidence of human BDV infection has also emerged recently. We examined the prevalence of BDV-specific antibodies in 432 Hong Kong Chinese patients with schizophrenia using Western blot technique as well as the relationship between seropositivity and clinical variables by comparing seropositve and seronegative patients. The serum samples of 480 healthy Hong Kong Chinese blood donors matched for age were used as controls. We found a significantly higher BDV seroprevalence rate in patients with schizophrenia Ž22.7%. than healthy blood donors Ž11.5%.. The odds ratio for BDV seropositivity was 2.27 Ž95% confidence intervals1.02–2.28.. No association between seropositivity and patient status, age, age of onset, duration of illness, duration of untreated psychosis, treatment response, subtype of illness, dosages of antipsychotic medication, the presence of family history of psychiatric disorder and scores on the PANSS was found. Our results suggest that BDV may be important in the pathogenesis of schizophrenia in Hong Kong and the significantly higher seropositivity rate amongpatients with schizophrenia is consistent with previous studies. Further research is indicated to clearly elucidate the characteristics of patients for whom BDV may be aetiologically relevant.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleBorna disease virus and Schizophrenia - a study of seroprevalence and clinical variablesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=53 &issue=suppl.&spage=84&epage=&date=2002&atitle=Borna+disease+virus+-+a+study+of+seroprevalence+and+clinical+variablesen_HK
dc.identifier.emailCheung, EFC: cheungfc@ha.org.hken_HK
dc.identifier.emailChen, RYL: rylchen@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.doi10.1016/S0920-9964(01)00381-4-
dc.identifier.hkuros73009en_HK
dc.identifier.volume53en_HK
dc.identifier.issue3 suppl. 1en_HK
dc.identifier.spage84, abstract A148en_HK
dc.identifier.epage84, abstract A148-

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