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Conference Paper: Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia

TitleEarly striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. In Schizophrenia Research, 2006, v. 81 suppl., p. 156, abstract no. 307 How to Cite?
AbstractBackground: We sought to determine whether brain volumetric differences are present in the early weeks of neuroleptic treatment in patients presenting in their first-episode of schizophrenia who had never previously been exposed to antipsychotic medication. Methods: We used a comprehensive computational morphometry analysis of the brain. 38 individuals with first-episode psychosis were balanced for age, sex, handedness, ethnicity, height, education in years, paternal socio-economic status and PANSS score. They were a consecutive series presenting to their local hospital for treatment. BAMM (Brain activation and morphological mapping)software was used to measure grey matter, white matter and CSF volumes. 12 were treated with neuroleptics (NT) and 26 were neuroleptic-naıve (NN). Groups did not differ in age, sex, socioeconomic class, handedness, ethnicity. In the NT group, significant clusters of volume excess in grey matter was detected bilaterally in the caudate, putamen, cingulate, cerebellum, and brainstem after around 18 days of neuroleptic treatment. Region-of-interest measurement of the caudate using T1 scans, 1.2mm, contiguous, 128 slices was done by a single operator blind to group membership. Results: Caudate volume significantly larger by 16% (on the left, p 0.012, 2 tailed) and 13% (on the right, p 0.028, 2 tailed) in the NT group. Conclusions: This is the first study to suggest that an increase (normalization) in striatal and extrastriatal grey matter volumes in Schizophrenia may occur as early as three weeks after neuroleptic treatment.
Persistent Identifierhttp://hdl.handle.net/10722/105331
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorCheung, JPYen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorTsang, JTKen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, KSen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorBullmore, Een_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2010-09-25T22:29:43Z-
dc.date.available2010-09-25T22:29:43Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, 4-10 February 2006. In Schizophrenia Research, 2006, v. 81 suppl., p. 156, abstract no. 307en_HK
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/105331-
dc.description.abstractBackground: We sought to determine whether brain volumetric differences are present in the early weeks of neuroleptic treatment in patients presenting in their first-episode of schizophrenia who had never previously been exposed to antipsychotic medication. Methods: We used a comprehensive computational morphometry analysis of the brain. 38 individuals with first-episode psychosis were balanced for age, sex, handedness, ethnicity, height, education in years, paternal socio-economic status and PANSS score. They were a consecutive series presenting to their local hospital for treatment. BAMM (Brain activation and morphological mapping)software was used to measure grey matter, white matter and CSF volumes. 12 were treated with neuroleptics (NT) and 26 were neuroleptic-naıve (NN). Groups did not differ in age, sex, socioeconomic class, handedness, ethnicity. In the NT group, significant clusters of volume excess in grey matter was detected bilaterally in the caudate, putamen, cingulate, cerebellum, and brainstem after around 18 days of neuroleptic treatment. Region-of-interest measurement of the caudate using T1 scans, 1.2mm, contiguous, 128 slices was done by a single operator blind to group membership. Results: Caudate volume significantly larger by 16% (on the left, p 0.012, 2 tailed) and 13% (on the right, p 0.028, 2 tailed) in the NT group. Conclusions: This is the first study to suggest that an increase (normalization) in striatal and extrastriatal grey matter volumes in Schizophrenia may occur as early as three weeks after neuroleptic treatment.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_HK
dc.titleEarly striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophreniaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCheung, V: cheungv@graduate.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.doi10.1016/j.schres.2006.01.006-
dc.identifier.hkuros143558en_HK
dc.identifier.hkuros115724-
dc.identifier.volume81en_HK
dc.identifier.issuesuppl.-
dc.identifier.spage156, abstract no. 307en_HK
dc.identifier.epage156, abstract no. 307-
dc.publisher.placeThe Netherlands-

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