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Conference Paper: Effects of haloperidol on serum brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients

TitleEffects of haloperidol on serum brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, v. 67 n. 1 suppl., p. 57, abstract no. 66 How to Cite?
AbstractBACKGROUND: Previous studies had reported that serum brain derived neurotrophic factor (BDNF) levels were decreased in chronic schizophrenic patients [Toyooka et al., 2002]. Recent evidence suggests that BDNF might be involved in antipsychotic action in the central nervous system, and some researchers have reported that prolonged treatment with haloperidol significantly down-regulates hippocampal BDNF protein level. However, it is unknown whether this antipsychotic drug has the similar effect on the peripheral system. In this study, we attempted to investigate the potential effect of haloperidol on patient’s serum BDNF level. METHODS: A case control study was performed on 22 chronic schizophrenic patients, under haloperidol treatment, and 22 normal controls, age and sex matched. BDNF level was measured by two site enzyme immunoassay (ELISA) method. No differences were found in the BDNF level between patients (41.46F10.72 ng/ml) and controls (38.41F7.55 ng/ml). CONCLUSION: Further research is under way to more fully understand the effect of drug treatment on serum BDNF levels and whether drug treatment normalizes serum BDNF levels.
Persistent Identifierhttp://hdl.handle.net/10722/105326
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorLiu, Pen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorHelmeste, DMen_HK
dc.date.accessioned2010-09-25T22:29:29Z-
dc.date.available2010-09-25T22:29:29Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, 7-13 February 2004. In Schizophrenia Research, v. 67 n. 1 suppl., p. 57, abstract no. 66en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105326-
dc.description.abstractBACKGROUND: Previous studies had reported that serum brain derived neurotrophic factor (BDNF) levels were decreased in chronic schizophrenic patients [Toyooka et al., 2002]. Recent evidence suggests that BDNF might be involved in antipsychotic action in the central nervous system, and some researchers have reported that prolonged treatment with haloperidol significantly down-regulates hippocampal BDNF protein level. However, it is unknown whether this antipsychotic drug has the similar effect on the peripheral system. In this study, we attempted to investigate the potential effect of haloperidol on patient’s serum BDNF level. METHODS: A case control study was performed on 22 chronic schizophrenic patients, under haloperidol treatment, and 22 normal controls, age and sex matched. BDNF level was measured by two site enzyme immunoassay (ELISA) method. No differences were found in the BDNF level between patients (41.46F10.72 ng/ml) and controls (38.41F7.55 ng/ml). CONCLUSION: Further research is under way to more fully understand the effect of drug treatment on serum BDNF levels and whether drug treatment normalizes serum BDNF levels.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.rightsSchizophrenia Research. Copyright © Elsevier BV.en_HK
dc.titleEffects of haloperidol on serum brain-derived neurotrophic factor (BDNF) levels in schizophrenic patientsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=67&issue=1&spage=57&epage=&date=2004&atitle=Effects+of+haloperidol+on+serum+brain-derived+neurotrophic+factor+(BDNF)+levels+in+schizophrenic+patientsen_HK
dc.identifier.emailTang, SW: mswtang@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.hkuros88266en_HK
dc.identifier.hkuros100473-
dc.identifier.volume67en_HK
dc.identifier.issue1 suppl.en_HK
dc.identifier.spage57, abstract no. 66en_HK
dc.identifier.epage57, abstract no. 66-

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