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Conference Paper: Developmental regulation of ionotropic glutamate receptors in central vestibular neurons in rats

TitleDevelopmental regulation of ionotropic glutamate receptors in central vestibular neurons in rats
Authors
Issue Date2009
Citation
The 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan, 16-18 September 2009 How to Cite?
AbstractTo investigate the role of ionotropic glutamate receptors (AMPARs and NMDARs) in the central vestibular neurons, whole-cell patch-clamp experiments were performed in spinal vestibular neurons of postnatal rats. The profiles of AMPARs and NMDARs were studied. From P1, glutamatergic transmission is primarily mediated by NMDARs. The relative contribution of AMPARs versus NMDARs at vestibular afferent synapses increased during the first two weeks of life. Using minimal stimulation procedures, NMDAR-only synapses were present only up to P5. In strontium-evoked miniatureEPSC recording, a significant increase in the quantal amplitude of AMPAR was observed from P5 to P7. These age-dependent increase of AMPARs towards the end of the first postnatal week coincides with the disappearance of NMDAR-only synapses. Taken together, our findings provide evidence on the developmental shift in AMPAR and NMDAR of glutamatergic synapses, contributing to functional maturation of central vestibular neurons in rats.
Persistent Identifierhttp://hdl.handle.net/10722/105270

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorWong, TPen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:27:07Z-
dc.date.available2010-09-25T22:27:07Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan, 16-18 September 2009-
dc.identifier.urihttp://hdl.handle.net/10722/105270-
dc.description.abstractTo investigate the role of ionotropic glutamate receptors (AMPARs and NMDARs) in the central vestibular neurons, whole-cell patch-clamp experiments were performed in spinal vestibular neurons of postnatal rats. The profiles of AMPARs and NMDARs were studied. From P1, glutamatergic transmission is primarily mediated by NMDARs. The relative contribution of AMPARs versus NMDARs at vestibular afferent synapses increased during the first two weeks of life. Using minimal stimulation procedures, NMDAR-only synapses were present only up to P5. In strontium-evoked miniatureEPSC recording, a significant increase in the quantal amplitude of AMPAR was observed from P5 to P7. These age-dependent increase of AMPARs towards the end of the first postnatal week coincides with the disappearance of NMDAR-only synapses. Taken together, our findings provide evidence on the developmental shift in AMPAR and NMDAR of glutamatergic synapses, contributing to functional maturation of central vestibular neurons in rats.-
dc.languageengen_HK
dc.relation.ispartofAnnual Meeting of the Japan Neuroscience Societyen_HK
dc.titleDevelopmental regulation of ionotropic glutamate receptors in central vestibular neurons in ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros158804en_HK

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