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Conference Paper: Otolithic influence on central cardiovascular control following natural vestibular stimulation in conscious rats

TitleOtolithic influence on central cardiovascular control following natural vestibular stimulation in conscious rats
Authors
Issue Date2001
PublisherSociety for Neuroscience
Citation
Neuroscience 2001, San Diego, CA, 10-15 November 2001. In Society for Neuroscience Abstracts, 2001, v. 27 n. 1, p. 788 Abstract no. 298.29 How to Cite?
AbstractTo investigate the effect of prolonged otolith activation on the cardiovascular system, constant velocity off-vertical axis rotations (OVAR), which selectively activate the otolith organs, were delivered to conscious Sprague Dawley rats for continuous periods of 3 hours. Mean blood pressure (MBP), heart rate (HR) and phenylephrine-induced baroreflex response were evaluated before and after the natural stimulation. In response to sustained OVAR, the basal HR was significantly lowered. Such reduction in HR, though not observed in stationary control, was significantly lower than that in labyrinthectomized control. However, no significant difference in basal MBP and baroreflex response was observed in all 3 groups. With the use of Fos immunohistochemistry and anterograde tracing (PHA-L) methods, functional connection between the vestibular nucleus and cardiovascular-related brainstem area was also examined. The projections of PHA-L axonal terminals from the vestibular nucleus were found in loci within the lateral parabrachial nucleus, Koelliker-Fuse nucleus, gigantocellular reticular formation, and medial aspect of rostroventral lateral medulla where Fos-positive neurons were located. In the control groups, neurons within these brainstem regions, which are known to actively participate in cardiovascular homeostasis, did not express Fos in the cell nuclei. Our findings suggest the involvement of these brainstem areas in coordinating otolith-induced cardiovascular adjustments following prolonged postural changes.
Persistent Identifierhttp://hdl.handle.net/10722/105259

 

DC FieldValueLanguage
dc.contributor.authorSun, Ben_HK
dc.contributor.authorGuan, ZLen_HK
dc.contributor.authorChan, RKWen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:26:40Z-
dc.date.available2010-09-25T22:26:40Z-
dc.date.issued2001en_HK
dc.identifier.citationNeuroscience 2001, San Diego, CA, 10-15 November 2001. In Society for Neuroscience Abstracts, 2001, v. 27 n. 1, p. 788 Abstract no. 298.29en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105259-
dc.description.abstractTo investigate the effect of prolonged otolith activation on the cardiovascular system, constant velocity off-vertical axis rotations (OVAR), which selectively activate the otolith organs, were delivered to conscious Sprague Dawley rats for continuous periods of 3 hours. Mean blood pressure (MBP), heart rate (HR) and phenylephrine-induced baroreflex response were evaluated before and after the natural stimulation. In response to sustained OVAR, the basal HR was significantly lowered. Such reduction in HR, though not observed in stationary control, was significantly lower than that in labyrinthectomized control. However, no significant difference in basal MBP and baroreflex response was observed in all 3 groups. With the use of Fos immunohistochemistry and anterograde tracing (PHA-L) methods, functional connection between the vestibular nucleus and cardiovascular-related brainstem area was also examined. The projections of PHA-L axonal terminals from the vestibular nucleus were found in loci within the lateral parabrachial nucleus, Koelliker-Fuse nucleus, gigantocellular reticular formation, and medial aspect of rostroventral lateral medulla where Fos-positive neurons were located. In the control groups, neurons within these brainstem regions, which are known to actively participate in cardiovascular homeostasis, did not express Fos in the cell nuclei. Our findings suggest the involvement of these brainstem areas in coordinating otolith-induced cardiovascular adjustments following prolonged postural changes.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleOtolithic influence on central cardiovascular control following natural vestibular stimulation in conscious ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros72038en_HK
dc.identifier.volume27en_HK
dc.identifier.spage29829en_HK

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