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Conference Paper: Expression of N-methyl-D-aspartate receptor subunits and induction of c-fos in otolith neurons in the vestibular nuclei of postnatal rats

TitleExpression of N-methyl-D-aspartate receptor subunits and induction of c-fos in otolith neurons in the vestibular nuclei of postnatal rats
Authors
Issue Date2000
PublisherSociety for Neuroscience
Citation
Neuroscience 2000, New Orleans, LA, 4-9 November 2000. In Society for Neuroscience Abstracts, 2000, v. 26 n. 1-2, p. 1494 Abstract no. 558.10 How to Cite?
AbstractThe developmental profile of functionally activated otolith neurons within the vestibular nucleus was examined in conscious young (P7-P28) and adult SD rats. Neuronal activation was defined by the expression of c-fos mRNA and/or Fos protein in response to constant velocity off-vertical axis rotation (OVAR), a stimulus that selectively activates otolith receptors. Labyrinthectomized rats subjected to OVAR showed only a few sporadically scattered labeled neurons. The pattern of c-fos expression in normal experimental rats was thus due to otolith activation. At P7, the number of Fos-positive vestibular nuclear neurons was small, contrasting those found in adults. This indicates that functional connection between central otolith neurons and peripheral receptors is established as early as P7. From P7 to P14, the number of Fos-positive vestibular nuclear neurons increased significantly and reached adult levels at P21. The cellular localization of NMDA receptor subunits in vestibular nuclei was also immunohistochemically examined. At P7, some OVAR-activated Fos-positive neurons expressed NMDA receptor subunits, indicating an early activation of glutaminergic central otolith neurons. The proportion of either NR1-Fos or NR2A/B-Fos double-labeled neurons progressively increased from P7 to adult, while the proportion of NR2C-Fos double-labeled neurons reached a maximum at P14. Our findings suggest that changes in the expression of NMDA receptor subunits in the first two postnatal weeks contribute to the mechanism of maturation in central otolith neurons.
Persistent Identifierhttp://hdl.handle.net/10722/105239

 

DC FieldValueLanguage
dc.contributor.authorLai, CHen_HK
dc.contributor.authorLaw, HYen_HK
dc.contributor.authorGuan, ZLen_HK
dc.contributor.authorYung, KKen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:25:51Z-
dc.date.available2010-09-25T22:25:51Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuroscience 2000, New Orleans, LA, 4-9 November 2000. In Society for Neuroscience Abstracts, 2000, v. 26 n. 1-2, p. 1494 Abstract no. 558.10en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105239-
dc.description.abstractThe developmental profile of functionally activated otolith neurons within the vestibular nucleus was examined in conscious young (P7-P28) and adult SD rats. Neuronal activation was defined by the expression of c-fos mRNA and/or Fos protein in response to constant velocity off-vertical axis rotation (OVAR), a stimulus that selectively activates otolith receptors. Labyrinthectomized rats subjected to OVAR showed only a few sporadically scattered labeled neurons. The pattern of c-fos expression in normal experimental rats was thus due to otolith activation. At P7, the number of Fos-positive vestibular nuclear neurons was small, contrasting those found in adults. This indicates that functional connection between central otolith neurons and peripheral receptors is established as early as P7. From P7 to P14, the number of Fos-positive vestibular nuclear neurons increased significantly and reached adult levels at P21. The cellular localization of NMDA receptor subunits in vestibular nuclei was also immunohistochemically examined. At P7, some OVAR-activated Fos-positive neurons expressed NMDA receptor subunits, indicating an early activation of glutaminergic central otolith neurons. The proportion of either NR1-Fos or NR2A/B-Fos double-labeled neurons progressively increased from P7 to adult, while the proportion of NR2C-Fos double-labeled neurons reached a maximum at P14. Our findings suggest that changes in the expression of NMDA receptor subunits in the first two postnatal weeks contribute to the mechanism of maturation in central otolith neurons.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleExpression of N-methyl-D-aspartate receptor subunits and induction of c-fos in otolith neurons in the vestibular nuclei of postnatal ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros60106en_HK
dc.identifier.volume26en_HK
dc.identifier.spage1494en_HK

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