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Conference Paper: Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats

TitleModulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats
Authors
KeywordsSubstance P
Parkinson's disease
Animal model
Basal ganglia
Issue Date2004
PublisherSociety for Neuroscience
Citation
Neuroscience 2004, San Diego, CA, 23-27 October 2004, Presentation no. 847.13 How to Cite?
AbstractParkinson's disease is a serious motor disorder which caused by a degeneration of dopaminergic neurons in the substantia nigra of the basal ganglia. Neurokinins (NK) are a group of neuropeptides that are implicated in the pathogenesis of Parkinson's disease. Objectives of the present study were to investigate the changes in expression of NK1 receptor in different neuronal elements of the striatum after the onset of Parkinson's disease using 6-hydroxydopamine-lesioned rat as an animal model. In lesioned rats, up-regulation of NK1 proteins was generally observed in the striatum by western blotting and immunofluorescence. In addition, double immunofluorescence revealed that NK1 immunoreactivity was primarily found in perikarya of striatal interneurons, namely the cholinergic, nitric oxide synthase-positive, parvalbumin-positive, and GluR1-immunoreactive interneurons. Interestingly, after lesion, a marked internalization of NK1 immunoreactivity was found in cholinergic interneurons and GluR1-positive neurons in the lesioned striatum. The present results indicate that expression of NK1 receptor is modulated in the striatum of the lesioned rats. The patterns of expression of NK1 receptor in striatal interneuron subpopulations are also modulated after dopamine denervation. NK1 receptor may therefore involve in the neuropathogenesis of Parkinson's disease. Supported by Joint Research Scheme, National Natural Science Foundation of China and Research Grants Council of Hong Kong, 30218002 and N_HKBU202/02
Persistent Identifierhttp://hdl.handle.net/10722/105237

 

DC FieldValueLanguage
dc.contributor.authorChan, WSen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorYung, KKen_HK
dc.date.accessioned2010-09-25T22:25:46Z-
dc.date.available2010-09-25T22:25:46Z-
dc.date.issued2004en_HK
dc.identifier.citationNeuroscience 2004, San Diego, CA, 23-27 October 2004, Presentation no. 847.13en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105237-
dc.description.abstractParkinson's disease is a serious motor disorder which caused by a degeneration of dopaminergic neurons in the substantia nigra of the basal ganglia. Neurokinins (NK) are a group of neuropeptides that are implicated in the pathogenesis of Parkinson's disease. Objectives of the present study were to investigate the changes in expression of NK1 receptor in different neuronal elements of the striatum after the onset of Parkinson's disease using 6-hydroxydopamine-lesioned rat as an animal model. In lesioned rats, up-regulation of NK1 proteins was generally observed in the striatum by western blotting and immunofluorescence. In addition, double immunofluorescence revealed that NK1 immunoreactivity was primarily found in perikarya of striatal interneurons, namely the cholinergic, nitric oxide synthase-positive, parvalbumin-positive, and GluR1-immunoreactive interneurons. Interestingly, after lesion, a marked internalization of NK1 immunoreactivity was found in cholinergic interneurons and GluR1-positive neurons in the lesioned striatum. The present results indicate that expression of NK1 receptor is modulated in the striatum of the lesioned rats. The patterns of expression of NK1 receptor in striatal interneuron subpopulations are also modulated after dopamine denervation. NK1 receptor may therefore involve in the neuropathogenesis of Parkinson's disease. Supported by Joint Research Scheme, National Natural Science Foundation of China and Research Grants Council of Hong Kong, 30218002 and N_HKBU202/02-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectSubstance P-
dc.subjectParkinson's disease-
dc.subjectAnimal model-
dc.subjectBasal ganglia-
dc.titleModulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros107364en_HK

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