File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: AMPA and NMDA receptor properties in spinal vestibular neurons of developing rats

TitleAMPA and NMDA receptor properties in spinal vestibular neurons of developing rats
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 143 How to Cite?
AbstractIonotropic glutamate receptors (AMPA and NMDA receptors) are important for signal transmission and synaptic plasticity in the vestibular system. However, contribution of the two types of ionotropic glutamate receptors to the coding of vestibular information during development remains unclear. Glutamatergic transmission in the spinal vestibular nucleus was studied in brainstem slices of P1–9 Sprague Dawley rats by whole-cell patchclamp approach. Analysis of miniature excitatory postsynaptic current (mEPSC) showed that both NMDA receptor- and AMPA receptor-mediated currents contributed equally to the mEPSC on or before P7. At P9, however, the AMPA component of the mEPSC became dominant ( 70%) as compared to the NMDA component. In response to electrical stimulation of the vestibular nerve, the evoked excitatory postsynaptic current (eEPSC) measured from brainstem slices was dominated by NMDA receptor-mediated current ( 70% of eEPSC) at P3/5. At P7/P9, the NMDA component decreased to 55% while the AMPA component increased to 45%. At P9, the linear I-V relationship of AMPA receptormediated eEPSC indicated the participation of GluR2 subunits in AMPA receptor. Our findings provide evidence that the functional maturation of spinal vestibular neurons may be related to the developmental profile of AMPA and NMDA receptors within glutamatergic synapses. Acknowledgement: Supported by HKRGC.
Persistent Identifierhttp://hdl.handle.net/10722/105197
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorTse, YCen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:24:08Z-
dc.date.available2010-09-25T22:24:08Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 143en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/105197-
dc.description.abstractIonotropic glutamate receptors (AMPA and NMDA receptors) are important for signal transmission and synaptic plasticity in the vestibular system. However, contribution of the two types of ionotropic glutamate receptors to the coding of vestibular information during development remains unclear. Glutamatergic transmission in the spinal vestibular nucleus was studied in brainstem slices of P1–9 Sprague Dawley rats by whole-cell patchclamp approach. Analysis of miniature excitatory postsynaptic current (mEPSC) showed that both NMDA receptor- and AMPA receptor-mediated currents contributed equally to the mEPSC on or before P7. At P9, however, the AMPA component of the mEPSC became dominant ( 70%) as compared to the NMDA component. In response to electrical stimulation of the vestibular nerve, the evoked excitatory postsynaptic current (eEPSC) measured from brainstem slices was dominated by NMDA receptor-mediated current ( 70% of eEPSC) at P3/5. At P7/P9, the NMDA component decreased to 55% while the AMPA component increased to 45%. At P9, the linear I-V relationship of AMPA receptormediated eEPSC indicated the participation of GluR2 subunits in AMPA receptor. Our findings provide evidence that the functional maturation of spinal vestibular neurons may be related to the developmental profile of AMPA and NMDA receptors within glutamatergic synapses. Acknowledgement: Supported by HKRGC.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeurosignalsen_HK
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.titleAMPA and NMDA receptor properties in spinal vestibular neurons of developing ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=15&spage=143&epage=&date=2006&atitle=AMPA+and+NMDA+receptor+properties+in+spinal+vestibular+neurons+of+developing+ratsen_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailZhou, H: zhouhua_01@163.comen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros137714en_HK
dc.identifier.volume15en_HK
dc.identifier.spage143en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats