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Conference Paper: Developmental profile of ionotropic glutamate receptors in spinal vestibular neurons of rats

TitleDevelopmental profile of ionotropic glutamate receptors in spinal vestibular neurons of rats
Authors
Issue Date2005
PublisherJapan Neuroscience Society
Citation
The 28th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 26-28 July 2005. In Neuroscience Research, 2005, v. 52 n. S1, p. S82 Abstract no. P1–082 How to Cite?
AbstractTo address the role of glutamate receptors in developing vestibular system, Fos-immunohistochemistry was first used to chart the maturation time course of spinal vestibular (SpV) neurons in the coding of vertical head movements. Conscious rats (P4 to adult) were subjected to vertical linear acceleration. Functionally activated Fos-ir neurons were first found at P7. 80% of Fos/NMDA or Fos/AMPA double-labeled neurons were observed in all age. Whole-cell patch clamp also used to study the maturation profile of excitatory postsynaptic currents evoked by the vestibular nerves stimulation (eEPSCs). From P3 to P5, eEPSCs were dominated by NMDAR-mediated component, viz. 70% NMDARmediated versus 20% AMPAR-mediated eEPSCs. From P7 to P9, NMDAR-mediated component decreased to 50% while AMPARmediated component increased to 40%. Altogether our findings suggested that changes in AMPAR and NMDAR components in glutamatergic synapses play a crucial role in the maturation of SpV neurons during the first postnatal week.
Persistent Identifierhttp://hdl.handle.net/10722/105167
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:22:55Z-
dc.date.available2010-09-25T22:22:55Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 28th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 26-28 July 2005. In Neuroscience Research, 2005, v. 52 n. S1, p. S82 Abstract no. P1–082en_HK
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/105167-
dc.description.abstractTo address the role of glutamate receptors in developing vestibular system, Fos-immunohistochemistry was first used to chart the maturation time course of spinal vestibular (SpV) neurons in the coding of vertical head movements. Conscious rats (P4 to adult) were subjected to vertical linear acceleration. Functionally activated Fos-ir neurons were first found at P7. 80% of Fos/NMDA or Fos/AMPA double-labeled neurons were observed in all age. Whole-cell patch clamp also used to study the maturation profile of excitatory postsynaptic currents evoked by the vestibular nerves stimulation (eEPSCs). From P3 to P5, eEPSCs were dominated by NMDAR-mediated component, viz. 70% NMDARmediated versus 20% AMPAR-mediated eEPSCs. From P7 to P9, NMDAR-mediated component decreased to 50% while AMPARmediated component increased to 40%. Altogether our findings suggested that changes in AMPAR and NMDAR components in glutamatergic synapses play a crucial role in the maturation of SpV neurons during the first postnatal week.-
dc.languageengen_HK
dc.publisherJapan Neuroscience Society-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleDevelopmental profile of ionotropic glutamate receptors in spinal vestibular neurons of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2005.04.001-
dc.identifier.hkuros121758en_HK
dc.identifier.spage182en_HK

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