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Conference Paper: Developmental responsiveness of vestibular-related brainstem neurons to horizontal rotational and translational motions

TitleDevelopmental responsiveness of vestibular-related brainstem neurons to horizontal rotational and translational motions
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 142 How to Cite?
AbstractTo investigate the distribution of functionally activated vestibular-related brainstem neurons during postnatal development, combined immuno-/hybridization histochemistry for c-fos expression was performed in Sprague-Dawley rats (P1–21; adult). Conscious animals were subjected to rotational or translational stimulus which activates hair cells on the horizontal semicircular canals or utricle, respectively. Neuronal activation within brainstem nuclei was defined by the expression of c-fos . Labyrinthectomized controls and normal stationary controls showed only a few sporadically scattered Fos-expressing neurons. During postnatal development, Fos-labeled vestibular nuclear (VN) neurons activated by cycles of constant angular acceleration and deceleration were observed by P4 while those by sinusoidal translational movement were not identifiable until P7. In both stimulation paradigms, an age-dependent increase in Fos-labeled neurons was observed in the VN and prepositus hypoglossal nucleus (PrH), the latter being a downstream area related to vestibulo-oculomotor function. In P7–9 rats, Fos-labeled neurons activated by canal or utricle input were evenly distributed throughout the rostro-caudal length of the VN complex (except the dorsal part of lateral VN) as well as groups x and y. At this age, PrH neurons were only activated with rotational stimulus and those activated with translational stimulus were not found until P11. In P21 and adult rats, the overlapping distribution of canal- and utricle-related Fos-labeled neurons was limited to the middle part of medial VN and caudal part of spinal VN. The rostral part of spinal VN was found to be constituted with neurons activated by translational motion. In the medial VN and PrH, a vast majority of the neurons was activated by rotational stimulus and only a small proportion was by translational stimulus. Taken together, we have demonstrated that canal- and otolith-related brainstem neurons that encode horizontal rotational and translational movements are histologically segregated and exhibit different developmental time frame. Acknowledgement: Supported by HKRGC.
Persistent Identifierhttp://hdl.handle.net/10722/105155
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorYiu, CNSen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:22:26Z-
dc.date.available2010-09-25T22:22:26Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 142en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/105155-
dc.description.abstractTo investigate the distribution of functionally activated vestibular-related brainstem neurons during postnatal development, combined immuno-/hybridization histochemistry for c-fos expression was performed in Sprague-Dawley rats (P1–21; adult). Conscious animals were subjected to rotational or translational stimulus which activates hair cells on the horizontal semicircular canals or utricle, respectively. Neuronal activation within brainstem nuclei was defined by the expression of c-fos . Labyrinthectomized controls and normal stationary controls showed only a few sporadically scattered Fos-expressing neurons. During postnatal development, Fos-labeled vestibular nuclear (VN) neurons activated by cycles of constant angular acceleration and deceleration were observed by P4 while those by sinusoidal translational movement were not identifiable until P7. In both stimulation paradigms, an age-dependent increase in Fos-labeled neurons was observed in the VN and prepositus hypoglossal nucleus (PrH), the latter being a downstream area related to vestibulo-oculomotor function. In P7–9 rats, Fos-labeled neurons activated by canal or utricle input were evenly distributed throughout the rostro-caudal length of the VN complex (except the dorsal part of lateral VN) as well as groups x and y. At this age, PrH neurons were only activated with rotational stimulus and those activated with translational stimulus were not found until P11. In P21 and adult rats, the overlapping distribution of canal- and utricle-related Fos-labeled neurons was limited to the middle part of medial VN and caudal part of spinal VN. The rostral part of spinal VN was found to be constituted with neurons activated by translational motion. In the medial VN and PrH, a vast majority of the neurons was activated by rotational stimulus and only a small proportion was by translational stimulus. Taken together, we have demonstrated that canal- and otolith-related brainstem neurons that encode horizontal rotational and translational movements are histologically segregated and exhibit different developmental time frame. Acknowledgement: Supported by HKRGC.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeurosignalsen_HK
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.titleDevelopmental responsiveness of vestibular-related brainstem neurons to horizontal rotational and translational motionsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=15&spage=142&epage=&date=2006&atitle=Developmental+responsiveness+of+vestibular-related+brainstem+neurons+to+horizontal+rotational+and+translational+motionsen_HK
dc.identifier.emailYiu, CNS: ngar650@yahoo.caen_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros137713en_HK
dc.identifier.volume15en_HK
dc.identifier.spage142en_HK

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