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Conference Paper: Postnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in rats

TitlePostnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in rats
Authors
KeywordsVESTIBULAR
MATURATION
IMMUNOHISTOCHEMISTRY
SPATIAL ORIENTATION
Issue Date2004
PublisherSociety for Neuroscience
Citation
Neuroscience 2004, San Diego, CA, 23-27 October 2004, Presentation no. 652.16 How to Cite?
AbstractTo investigate the maturation profile of AMPA receptor subunits (GluR1-4) and the glutamate transporter (EAAC1) in saccule-related neurons within the vestibular nucleus and its subgroups, immunohistochemcial experiments were performed in Sprague-Dawleys rats (P4–adults). All conscious rats were subjected to sinusoidal linear acceleration along the vertical plane, thereby activating the saccule of the inner ear. Controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming the saccular origin of c-fos expression. Functionally activated Fos-labeled neurons expressing either EAAC1 or AMPA receptor subunits were first identified at P7 in medial vestibular nucleus (MV), spinal vestibular nucleus (SpV) and group x. Such double-labeled neurons were however not observed in group y until P9. Despite the increase in Fos-labeled neurons with age, Fos/EAAC1 double-labeled neurons in SpV, MV, group x, and group y progressively decreased from 80% of Fos-labeled neurons to 30% in the adult. While 80% of the neurons in MV, SpV, and group x co-expressed Fos and AMPA receptor subunits in all age groups, those in group y decreased after the second postnatal week, reaching 10-30% in the adult. Our findings suggest that neurons in different vestibular subnuclei utilize different postsynaptic mechanisms to process gravity-related vertical spatial information. Supported by HK RGC
Persistent Identifierhttp://hdl.handle.net/10722/105144

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:21:59Z-
dc.date.available2010-09-25T22:21:59Z-
dc.date.issued2004en_HK
dc.identifier.citationNeuroscience 2004, San Diego, CA, 23-27 October 2004, Presentation no. 652.16en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105144-
dc.description.abstractTo investigate the maturation profile of AMPA receptor subunits (GluR1-4) and the glutamate transporter (EAAC1) in saccule-related neurons within the vestibular nucleus and its subgroups, immunohistochemcial experiments were performed in Sprague-Dawleys rats (P4–adults). All conscious rats were subjected to sinusoidal linear acceleration along the vertical plane, thereby activating the saccule of the inner ear. Controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming the saccular origin of c-fos expression. Functionally activated Fos-labeled neurons expressing either EAAC1 or AMPA receptor subunits were first identified at P7 in medial vestibular nucleus (MV), spinal vestibular nucleus (SpV) and group x. Such double-labeled neurons were however not observed in group y until P9. Despite the increase in Fos-labeled neurons with age, Fos/EAAC1 double-labeled neurons in SpV, MV, group x, and group y progressively decreased from 80% of Fos-labeled neurons to 30% in the adult. While 80% of the neurons in MV, SpV, and group x co-expressed Fos and AMPA receptor subunits in all age groups, those in group y decreased after the second postnatal week, reaching 10-30% in the adult. Our findings suggest that neurons in different vestibular subnuclei utilize different postsynaptic mechanisms to process gravity-related vertical spatial information. Supported by HK RGC-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectVESTIBULAR-
dc.subjectMATURATION-
dc.subjectIMMUNOHISTOCHEMISTRY-
dc.subjectSPATIAL ORIENTATION-
dc.titlePostnatal expression of AMPA receptor subunits and glutamate transporter EAAC1 in saccule-related vestibular nuclear neurons in ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros107349en_HK
dc.identifier.spage65216en_HK

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