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Conference Paper: Neonatal hypoxia protects against hypoxic adaptation pulmonary vasculature in adults

TitleNeonatal hypoxia protects against hypoxic adaptation pulmonary vasculature in adults
Authors
Issue Date2007
PublisherFederation of American Societies for Experimental Biology.
Citation
The 2007 Meeting of Experimental Biology (EB 2007), Washington, DC., 28 April-2 May 2007. In The FASEB Journal, 2007, v. 21 n. 6, p. A1288, abstract no. 917.12 How to Cite?
AbstractWe investigated whether neonatal hypoxia altered the subsequent adaptation to hypoxia in adults. 3 groups of neonatal rats were used: NNH rats were normoxic for 6 weeks then hypoxic for 4 weeks; HNH rats were hypoxic for 2 weeks, normoxic for 4 weeks, then hypoxic for 4 weeks; NNN rats were normoxic for 10 weeks. The pulmonary circulation was perfused in-situ: perfusion pressure was 17.6 ± 3.4, 40.9 ± 6.0 and 31.5 ± 2.7 mmHg in NNN, NNH and HNH rats, respectively. Endothelin (10μM) increased perfusion pressure to 21.5 ± 2.7, 52.9 ± 6.4 and 40.9 ± 3.1 mmHg in NNN, NNH and HNH rats. Endothelin dose-response curves of isolated pulmonary arterial rings were similar in all groups at 6 weeks (prior to the second hypoxic exposure); rings from NNH rats showed depressed ETA-mediated constriction at 10 weeks (after the hypoxic exposure), whereas those from HNH rats were similar to NNN. Rats were returned to normoxia for a further 4 weeks: endothelin (500μM) increased vascular contraction by 123 ± 7, 188 ± 6 or 83 ± 11 % in NNN, NNH or HNH. These data suggest that brief exposure to hypoxia in the neonatal period confers protection against pulmonary vascular hypertrophy and altered vascular reactivity upon exposure to hypoxia as an adult. Funded by The Institute of Cardiovascular Science & Medicine, Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/105139
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorBallard, HJen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorDas, Ren_HK
dc.contributor.authorFung, MLen_HK
dc.date.accessioned2010-09-25T22:21:47Z-
dc.date.available2010-09-25T22:21:47Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2007 Meeting of Experimental Biology (EB 2007), Washington, DC., 28 April-2 May 2007. In The FASEB Journal, 2007, v. 21 n. 6, p. A1288, abstract no. 917.12en_HK
dc.identifier.issn0892-6638en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105139-
dc.description.abstractWe investigated whether neonatal hypoxia altered the subsequent adaptation to hypoxia in adults. 3 groups of neonatal rats were used: NNH rats were normoxic for 6 weeks then hypoxic for 4 weeks; HNH rats were hypoxic for 2 weeks, normoxic for 4 weeks, then hypoxic for 4 weeks; NNN rats were normoxic for 10 weeks. The pulmonary circulation was perfused in-situ: perfusion pressure was 17.6 ± 3.4, 40.9 ± 6.0 and 31.5 ± 2.7 mmHg in NNN, NNH and HNH rats, respectively. Endothelin (10μM) increased perfusion pressure to 21.5 ± 2.7, 52.9 ± 6.4 and 40.9 ± 3.1 mmHg in NNN, NNH and HNH rats. Endothelin dose-response curves of isolated pulmonary arterial rings were similar in all groups at 6 weeks (prior to the second hypoxic exposure); rings from NNH rats showed depressed ETA-mediated constriction at 10 weeks (after the hypoxic exposure), whereas those from HNH rats were similar to NNN. Rats were returned to normoxia for a further 4 weeks: endothelin (500μM) increased vascular contraction by 123 ± 7, 188 ± 6 or 83 ± 11 % in NNN, NNH or HNH. These data suggest that brief exposure to hypoxia in the neonatal period confers protection against pulmonary vascular hypertrophy and altered vascular reactivity upon exposure to hypoxia as an adult. Funded by The Institute of Cardiovascular Science & Medicine, Hong Kong.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology.en_HK
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleNeonatal hypoxia protects against hypoxic adaptation pulmonary vasculature in adultsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-6638&volume=21&issue=6&spage=&epage=&date=2007&atitle=Neonatal+hypoxia+protects+against+hypoxic+adaptation+pulmonary+vasculature+in+adultsen_HK
dc.identifier.emailBallard, HJ: ballard@hkucc.hku.hken_HK
dc.identifier.emailDas, R: raptidas@hkucc.hku.hken_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.authorityBallard, HJ=rp00367en_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.identifier.hkuros137830en_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spageA1288, abstract no. 917.12-
dc.identifier.epageA1288, abstract no. 917.12-

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