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Conference Paper: Discharge pattern and corticofugal control of OFF/ON-OFF neurons in the guinea pig auditory thalamus: an in-vivo intracellular study

TitleDischarge pattern and corticofugal control of OFF/ON-OFF neurons in the guinea pig auditory thalamus: an in-vivo intracellular study
Authors
KeywordsOffset response
Medial geniculate body
Corticofugal modulation
Acoutic stimulus
Issue Date2002
PublisherSociety for Neuroscience
Citation
Neuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 354.4 How to Cite?
AbstractNeuronal responses to noise bursts/pure tones in medial geniculate body (MGB) were examined intracellularly while the auditory cortex of the pentobarbital-sodium-anesthetized guinea pig was activated through electrical current. 24 OFF and 7 ON-OFF neurons were recorded in the MGB. The OFF response ranged from 1 to 15 spikes. 9 neurons showed an inhibition during the presence of the acoustic stimulus and followed by a low-threshold-calcium spike burst after the offset of the stimulus. The buildup and decay of the low-threshold spike/burst of OFF responses were different from those of the ON responses, suggesting that different neural mechanisms are involved in generating the responses. Of two neurons tested with the duration selectivity, both were long-duration-selective. Cortical activation elicited either an elevation or a depression in the membrane potential of the thalamic OFF/ON-OFF neurons with long time constants up to 1 s. Cortical activation could cause facilitations/inhibitions in both the ON and OFF components, or either ON or OFF components depending on the resting membrane potential. Supported by Research Grants Council of Hong Kong: PolyU5211/99M
Persistent Identifierhttp://hdl.handle.net/10722/105136

 

DC FieldValueLanguage
dc.contributor.authorYu, YQen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, JFen_HK
dc.date.accessioned2010-09-25T22:21:40Z-
dc.date.available2010-09-25T22:21:40Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 354.4en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105136-
dc.description.abstractNeuronal responses to noise bursts/pure tones in medial geniculate body (MGB) were examined intracellularly while the auditory cortex of the pentobarbital-sodium-anesthetized guinea pig was activated through electrical current. 24 OFF and 7 ON-OFF neurons were recorded in the MGB. The OFF response ranged from 1 to 15 spikes. 9 neurons showed an inhibition during the presence of the acoustic stimulus and followed by a low-threshold-calcium spike burst after the offset of the stimulus. The buildup and decay of the low-threshold spike/burst of OFF responses were different from those of the ON responses, suggesting that different neural mechanisms are involved in generating the responses. Of two neurons tested with the duration selectivity, both were long-duration-selective. Cortical activation elicited either an elevation or a depression in the membrane potential of the thalamic OFF/ON-OFF neurons with long time constants up to 1 s. Cortical activation could cause facilitations/inhibitions in both the ON and OFF components, or either ON or OFF components depending on the resting membrane potential. Supported by Research Grants Council of Hong Kong: PolyU5211/99M-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectOffset response-
dc.subjectMedial geniculate body-
dc.subjectCorticofugal modulation-
dc.subjectAcoutic stimulus-
dc.titleDischarge pattern and corticofugal control of OFF/ON-OFF neurons in the guinea pig auditory thalamus: an in-vivo intracellular studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros82107en_HK

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