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Conference Paper: Corticofugal inhibition on the auditory thalamic neurons: an in-vivo intracellular electrophysiological study

TitleCorticofugal inhibition on the auditory thalamic neurons: an in-vivo intracellular electrophysiological study
Authors
KeywordsMedial geniculate body
Tectothalamic projection
Corticofugal modulation
Electrical stimulation
Issue Date2002
PublisherSociety for Neuroscience
Citation
Neuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 354.3 How to Cite?
AbstractOur recent studies of extracellular and intracellular recordings have shown that the corticofugal projection has a strong inhibition on the medial geniculate body (MGB), especially on its non-lemniscal nuclei. The inhibition is suggested to be caused potentially by the following inhibitory neurons which can be activated by the corticofugal projection: 1) the thalamic interneurons 2) the thalamic reticular neurons, and 3) the inferior collicular inhibitory neurons which directly project to the MGB. In the present study, we examined the contribution of the corticocolliculothalamic pathway on the strong corticothalamic inhibition by comparing neuronal responses to the cortical electrical stimulation between the experimental condition with the colliculothalamic projection sectioned and the control condition in which the colliculothalamic projection was kept intact. 90 thalamic neurons from 8 anesthetized guinea pigs were recorded intracellularly while the auditory cortex was activated through an electrical stimulation of pulse trains. Strong corticofugal inhibitions were confirmed in the thalamic neurons after the section of the auditory colliculothalamic connections. The inhibitory effects lasted for 247.1-317.7 ms in the same order as before the sectioning. Both the sectioning and the recording sites were anatomically confirmed. We conclude that the strong corticofugal inhibition on the MGB is mainly caused by the thalamic reticular nucleus. Supported by RGC (PolyU5211/99M) and PolyU (G-T253)
Persistent Identifierhttp://hdl.handle.net/10722/105123

 

DC FieldValueLanguage
dc.contributor.authorFujimoto, Ken_HK
dc.contributor.authorYu, YQen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, JFen_HK
dc.date.accessioned2010-09-25T22:21:08Z-
dc.date.available2010-09-25T22:21:08Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 354.3en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105123-
dc.description.abstractOur recent studies of extracellular and intracellular recordings have shown that the corticofugal projection has a strong inhibition on the medial geniculate body (MGB), especially on its non-lemniscal nuclei. The inhibition is suggested to be caused potentially by the following inhibitory neurons which can be activated by the corticofugal projection: 1) the thalamic interneurons 2) the thalamic reticular neurons, and 3) the inferior collicular inhibitory neurons which directly project to the MGB. In the present study, we examined the contribution of the corticocolliculothalamic pathway on the strong corticothalamic inhibition by comparing neuronal responses to the cortical electrical stimulation between the experimental condition with the colliculothalamic projection sectioned and the control condition in which the colliculothalamic projection was kept intact. 90 thalamic neurons from 8 anesthetized guinea pigs were recorded intracellularly while the auditory cortex was activated through an electrical stimulation of pulse trains. Strong corticofugal inhibitions were confirmed in the thalamic neurons after the section of the auditory colliculothalamic connections. The inhibitory effects lasted for 247.1-317.7 ms in the same order as before the sectioning. Both the sectioning and the recording sites were anatomically confirmed. We conclude that the strong corticofugal inhibition on the MGB is mainly caused by the thalamic reticular nucleus. Supported by RGC (PolyU5211/99M) and PolyU (G-T253)-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectMedial geniculate body-
dc.subjectTectothalamic projection-
dc.subjectCorticofugal modulation-
dc.subjectElectrical stimulation-
dc.titleCorticofugal inhibition on the auditory thalamic neurons: an in-vivo intracellular electrophysiological studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros82104en_HK

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