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Conference Paper: Cortical activation on temporal expression of FOS in various nuclei of themedial geniculate body of cochlear-ablated rats

TitleCortical activation on temporal expression of FOS in various nuclei of themedial geniculate body of cochlear-ablated rats
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
The 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S11 How to Cite?
AbstractTo investigate the organization of corticothalamic projection in the auditory pathway, we examined the time course of Fos expression in medial geniculate body (MGB) neurons after chemical activation of the auditory cortex in cochlearablated Sprague–Dawley rats. The cochlea of pentobarbitalanesthetized rats were bilaterally removed and the animals were allowed to recover for 4 h (group I), 24 h (group II) or 7 days (group III). These rats were then anesthetized with pentobarbital again. The auditory cortex on one side was injected with bicuculline methobromide (20 mM), which activates cell bodies but not fibers of passage. At 1 h after this injection, the brain was processed for immunohistochemical expression of Fos protein. Neuronal activation was indicated by Fos expression in cell nuclei. In group-I rats, Fos expression was mainly restricted in the central region of the ventral nucleus of the MGB ipsilateral to the activated hemisphere and the medial nucleus of the MGB. In group-II and group-III rats, Fos expression was mainly located in the marginal zone, the dorsal and medial nuclei of the MGB ipsilateral to the activated hemisphere. The spatial distribution and the number of Fos-immunoreactive MGB neurons in group-III rats were larger than those of group II. Our results indicate that the corticofugal-induced neuronal excitability in the non-ventral MGB exhibits a different time course than that in the ventral MGB after cochlear ablation.
Persistent Identifierhttp://hdl.handle.net/10722/105067
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035

 

DC FieldValueLanguage
dc.contributor.authorSun, Xen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-09-25T22:18:52Z-
dc.date.available2010-09-25T22:18:52Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S11en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105067-
dc.description.abstractTo investigate the organization of corticothalamic projection in the auditory pathway, we examined the time course of Fos expression in medial geniculate body (MGB) neurons after chemical activation of the auditory cortex in cochlearablated Sprague–Dawley rats. The cochlea of pentobarbitalanesthetized rats were bilaterally removed and the animals were allowed to recover for 4 h (group I), 24 h (group II) or 7 days (group III). These rats were then anesthetized with pentobarbital again. The auditory cortex on one side was injected with bicuculline methobromide (20 mM), which activates cell bodies but not fibers of passage. At 1 h after this injection, the brain was processed for immunohistochemical expression of Fos protein. Neuronal activation was indicated by Fos expression in cell nuclei. In group-I rats, Fos expression was mainly restricted in the central region of the ventral nucleus of the MGB ipsilateral to the activated hemisphere and the medial nucleus of the MGB. In group-II and group-III rats, Fos expression was mainly located in the marginal zone, the dorsal and medial nuclei of the MGB ipsilateral to the activated hemisphere. The spatial distribution and the number of Fos-immunoreactive MGB neurons in group-III rats were larger than those of group II. Our results indicate that the corticofugal-induced neuronal excitability in the non-ventral MGB exhibits a different time course than that in the ventral MGB after cochlear ablation.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleCortical activation on temporal expression of FOS in various nuclei of themedial geniculate body of cochlear-ablated ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=370 Suppl&spage=S11&epage=&date=2004&atitle=Cortical+activation+on+temporal+expression+of+Fos+in+various+nuclei+of+the+medial+geniculate+body+of+cochlear-ablated+rats.en_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2004.09.001-
dc.identifier.hkuros107311en_HK
dc.identifier.volume370en_HK
dc.identifier.spageS11en_HK

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