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Conference Paper: Developmental profile of central otolith neurons in the detection of vertical linear acceleration

TitleDevelopmental profile of central otolith neurons in the detection of vertical linear acceleration
Authors
KeywordsVESTIBULAR
MATURATION
IMMUNOHISTOCHEMISTRY
SPATIAL ORIENTATION
Issue Date2002
PublisherSociety for Neuroscience
Citation
Neuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 564.12 How to Cite?
AbstractTo investigate the time course of maturation of central otolith neurons in coding vertical head movements, Fos-immunohistochemical experiments were performed in an age-graded series of Sprague Dawley rats (P4 - 84). All conscious animals were subjected to sinusoidal linear acceleration along the vertical plane, thereby activating the saccules in the inner ear. In control experiments, labyrinthectomized rats subjected to accelerations and normal rats that remained stationary showed only sporadically labeled neurons in the vestibular nucleus and the neighboring prepositus hypoglossal nucleus. Functionally activated Fos-immunolabeled neurons were first identified at P7 in spinal vestibular nucleus, medial vestibular nucleus, group x, and prepositus hypoglossal nucleus. However, it is of interest to note that in group y, a region that receives heavy afferent input from the saccule, Fos-labeled neurons were only found from P9 onwards. The number of functionally activated neurons in these otolith-related areas gradually increased with age and reached adult level at P28. Our findings therefore reveal the developmental profile of central otolith neurons in coding vertical head movements during the first postnatal month. Supported by HK RGC
Persistent Identifierhttp://hdl.handle.net/10722/105063

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:18:43Z-
dc.date.available2010-09-25T22:18:43Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 564.12en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105063-
dc.description.abstractTo investigate the time course of maturation of central otolith neurons in coding vertical head movements, Fos-immunohistochemical experiments were performed in an age-graded series of Sprague Dawley rats (P4 - 84). All conscious animals were subjected to sinusoidal linear acceleration along the vertical plane, thereby activating the saccules in the inner ear. In control experiments, labyrinthectomized rats subjected to accelerations and normal rats that remained stationary showed only sporadically labeled neurons in the vestibular nucleus and the neighboring prepositus hypoglossal nucleus. Functionally activated Fos-immunolabeled neurons were first identified at P7 in spinal vestibular nucleus, medial vestibular nucleus, group x, and prepositus hypoglossal nucleus. However, it is of interest to note that in group y, a region that receives heavy afferent input from the saccule, Fos-labeled neurons were only found from P9 onwards. The number of functionally activated neurons in these otolith-related areas gradually increased with age and reached adult level at P28. Our findings therefore reveal the developmental profile of central otolith neurons in coding vertical head movements during the first postnatal month. Supported by HK RGC-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectVESTIBULAR-
dc.subjectMATURATION-
dc.subjectIMMUNOHISTOCHEMISTRY-
dc.subjectSPATIAL ORIENTATION-
dc.titleDevelopmental profile of central otolith neurons in the detection of vertical linear accelerationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros82121en_HK

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