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Conference Paper: Developmental Expression of Fos Protein in Horizontal Canal-Related Vestibular Nuclear Neurons of Postnatal Rats following Angular Acceleration

TitleDevelopmental Expression of Fos Protein in Horizontal Canal-Related Vestibular Nuclear Neurons of Postnatal Rats following Angular Acceleration
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 132-133 How to Cite?
AbstractTo investigate the postnatal distribution of horizontal canalrelated neurons within the vestibular nucleus, conscious young (1–21 days) and adult Sprague-Dawley rats were subjected to constant angular acceleration on the horizontal plane for 60 minutes. This stimulation paradigm, composed of alternate modes of angular acceleration (at 50–200º/s 2 ) in the clockwise (8s) and counterclockwise direction (8s), activates hair cells in both horizontal canals. Neuronal activation within brainstem nuclei was defined by the expression of Fos protein. Labyrinthectomized controls and normal stationary controls showed only a few sporadically scattered Fos-labeled eurons. In P1–4 rats, no Fos-labeled neurons were found in the vestibular nucleus and prepositus hypoglossal nucleus (PrH). In the vestibular nucleus, significant Fos labelling was identified in the medial (MV), spinal (SpV) nuclei and group ! subnucleus as early as P5. From P5 to P14, Fos expression in both the MV and SpV progressively increased, reaching an adult level at P21. In P5–7 rats, Fos-labeled neurons, though few in number, were evenly distributed throughout the entire rostrocaudal length of the MV and SpV. In P21 and adult rats, however, the number of Fos-labeled neurons tended to cluster in the caudal end of the MV and SpV. In the PrH, an area related to vestibulo-ocular functions, an age-dependent increase in the number of Fos-labeled neurons was observed from P7 onwards. These were mainly distributed in the rostral PrH. The present results provide evidence that functional connectivity between canal receptors and central vestibular neurons is established during the first postnatal week. Acknowledgement: Supported by HK RGC.
Persistent Identifierhttp://hdl.handle.net/10722/105062
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorYiu, CNSen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:18:40Z-
dc.date.available2010-09-25T22:18:40Z-
dc.date.issued2006en_HK
dc.identifier.citationThe Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 132-133en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/105062-
dc.description.abstractTo investigate the postnatal distribution of horizontal canalrelated neurons within the vestibular nucleus, conscious young (1–21 days) and adult Sprague-Dawley rats were subjected to constant angular acceleration on the horizontal plane for 60 minutes. This stimulation paradigm, composed of alternate modes of angular acceleration (at 50–200º/s 2 ) in the clockwise (8s) and counterclockwise direction (8s), activates hair cells in both horizontal canals. Neuronal activation within brainstem nuclei was defined by the expression of Fos protein. Labyrinthectomized controls and normal stationary controls showed only a few sporadically scattered Fos-labeled eurons. In P1–4 rats, no Fos-labeled neurons were found in the vestibular nucleus and prepositus hypoglossal nucleus (PrH). In the vestibular nucleus, significant Fos labelling was identified in the medial (MV), spinal (SpV) nuclei and group ! subnucleus as early as P5. From P5 to P14, Fos expression in both the MV and SpV progressively increased, reaching an adult level at P21. In P5–7 rats, Fos-labeled neurons, though few in number, were evenly distributed throughout the entire rostrocaudal length of the MV and SpV. In P21 and adult rats, however, the number of Fos-labeled neurons tended to cluster in the caudal end of the MV and SpV. In the PrH, an area related to vestibulo-ocular functions, an age-dependent increase in the number of Fos-labeled neurons was observed from P7 onwards. These were mainly distributed in the rostral PrH. The present results provide evidence that functional connectivity between canal receptors and central vestibular neurons is established during the first postnatal week. Acknowledgement: Supported by HK RGC.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeurosignalsen_HK
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.titleDevelopmental Expression of Fos Protein in Horizontal Canal-Related Vestibular Nuclear Neurons of Postnatal Rats following Angular Accelerationen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=15&spage=132&epage=133&date=2006&atitle=Developmental+expression+of+Fos+protein+in+horizontal-canal+related+vestibular+nuclear+neurons+of+postnatal+rat+following+angular+accelerationen_HK
dc.identifier.emailYiu, CNS: ngar650@yahoo.caen_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros137697en_HK
dc.identifier.volume15en_HK
dc.identifier.spage132en_HK
dc.identifier.epage133en_HK

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